High Sensitivity C Reactive Protein: An Adjunct Diagnosis in Ruling Out Pediatric Tuberculosis

  • Bineeta KashyapEmail author
  • Neha Gupta
  • Pooja Dewan
  • Puneeta Hyanki
  • N. P. Singh
Original Research Article


The utility of C-reactive protein (CRP) as a marker of disease severity, therapeutic response and prognosis in tuberculosis has been suggested. This study aims to determine the levels of high sensitivity CRP (hs CRP) among the pediatric tuberculosis cases. A case control study was conducted on 60 clinically diagnosed (clinical findings and radiography and/or contact history and/or Mantoux test) or microbiologically confirmed (smear and/or culture and/or Cartridge based Nucleic Acid Amplification test positive) pediatric tuberculosis cases ≤ 12 years. hs CRP levels were estimated in the cases and healthy controls using ELISA. Median levels of serum hs CRP were significantly higher in pediatric tuberculosis cases (25 mg/l) as compared to controls (0.530 mg/l). No significant correlation was found with age, gender, site of tuberculosis or presence of dissemination. Lower levels were found with palpable lymphadenopathy. Levels were not significantly different between microbiologically confirmed cases and those who were negative by one or more of the microbiological tests of staining, culture and cartridge based nucleic acid amplification test. hs CRP can be used in diagnostic algorithms of pediatric tuberculosis to rule out tuberculosis. Further studies could help in determining the prognostic and therapeutic response of hs CRP among children leading to better management.


hs CRP Pediatric Tuberculosis Diagnosis 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Association of Clinical Biochemists of India 2019

Authors and Affiliations

  1. 1.Department of MicrobiologyUniversity College of Medical Sciences and Guru Teg Bahadur HospitalNew DelhiIndia
  2. 2.Department of PediatricsUniversity College of Medical Sciences and Guru Teg Bahadur HospitalNew DelhiIndia
  3. 3.DOTS CenterUniversity College of Medical Sciences and Guru Teg Bahadur HospitalNew DelhiIndia
  4. 4.New DelhiIndia

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