Tacrolimus Induced Diabetic Ketoacidosis Following Hematopoietic Stem Cell Transplantation

  • Sanjeev Kumar SharmaEmail author
  • Divya Doval
  • Vipin Khandelwal
  • Meet Kumar
  • Dharma Choudhary
Short Communication


Risk of diabetes mellitus increases after solid organ and hematopoietic stem cell transplantation. Diabetic ketoacidosis has been reported after solid organ transplantation in patients receiving tacrolimus but has rarely been reported after stem cell transplantation. The major risk factors for diabetic ketoacidosis are immunosuppressive drugs used after transplantation. We report here three cases of allogenic stem cell transplant who developed diabetic ketoacidosis while on treatment with tacrolimus. The drug was stopped in all the cases and patients were treated with insulin therapy resulting in complete recovery from diabetic ketoacidosis.


Tacrolimus Stem cell transplant Diabetic ketoacidosis 



We are thankful to Ms Bharti for collecting the data.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2019

Authors and Affiliations

  1. 1.Department of Hemato-Oncology and Bone Marrow TransplantationBLK Superspeciality HospitalNew DelhiIndia

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