Anaplastic Diffuse Large B Cell Lymphoma: A Single Center Experience

  • Neha SinghEmail author
  • Ridhi Sood
  • Narendra Agrawal
  • Sunil Pasricha
  • Anurag Mehta

Dear Sir,

The Anaplastic Diffuse Large B cell Lymphoma (A-DLBCL) is an uncommon distinct morphologic variant of DLBCL characterized by large polygonal cells with bizarre pleomorphic nuclei resembling tumor cells of anaplastic large cell lymphoma (ALCL) or even Reed-Sternberg cells of Hodgkin Lymphoma with a cohesive or sinusoidal growth pattern. A-DLBCL can also simulate malignant melanoma or undifferentiated carcinoma [1, 2]. It accounts for 1–3.5% of all newly diagnosed DLBCL cases according to different studies [3]. Diagnosis of A-DLBCL relies primarily on morphology and extensive immunohistochemical work-up in the absence of any single specific marker as the chances of false positive or erroneous diagnosis of A-DLBCL are higher due to close resemblance to other differentials such as ALCL, EBV-Positive DLBCL, ALK-Positive DLBCL and Hodgkin Lymphoma. Cases of A-DLBCL with hallmark cell appearance indistinguishable from common and giant cell-rich patterns of ALCL [4] and case reports...


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Conflict of interest

The authors state that there is no conflict of interest present.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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© Indian Society of Hematology and Blood Transfusion 2019

Authors and Affiliations

  1. 1.Department of Pathology and Lab ServicesRajiv Gandhi Cancer Institute and Research CenterRohiniIndia
  2. 2.Department of Hemato-OncologyRajiv Gandhi Cancer Institute and Research CenterRohiniIndia

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