Treatment Related Acute Myeloid Leukemia in Breast Cancer Survivors: A Single Institutional Experience
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Breast cancer is the most common malignancy among Indian women. With the growing population of breast cancer survivors, the oncologists are confronted with plethora of treatment (chemotherapy, radiotherapy) related adverse effects like fatigue, cardiac toxicities, sexual dysfunction, and second malignancies. A SEER data reported an incidence of 1.8% acute myeloid leukemia (AML) among breast cancer survivors treated with chemotherapy after a period of 10 years follow up [ 1]. Data of treatment related AML (tAML) in breast cancer survivors from our country is limited [ 2]. Hence, we conducted a retrospective analysis of 7 cases of tAML following breast cancer treatment in medical oncology department of BRA-IRCH from 2006 to 2017. The baseline characteristics and outcome are tabulated in Table 1. The median age of diagnosis of tAML was 60 years. All 7 cases received adjuvant chemotherapy, out of which 5 received 5-fluorouracil 500 mg/m 2, epirubicin 75 mg/m 2and...
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Conflict of interest
The authors declare that they have no conflict of interest.
Institute ethical clearance was obtained for the retrospective study.
© Indian Society of Hematology and Blood Transfusion 2019