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Chromosome 12 Rearrangement in an Adolescent with Primary Myelofibrosis

  • Moeinadin Safavi
  • Atoosa Gharib
  • Mohammad Taghi Haghi Ashtiani
  • Poorya Salajegheh
  • Mohammad Vasei
Correspondence
  • 5 Downloads

Dear Editor,

Primary myelofibrosis (PMF) is a Philadelphia negative myeloproliferative neoplasm with bone marrow megakaryocytic and granulocytic proliferation along with fibrosis and extramedullary hematopoiesis. There is a sequential evolution in PMF from a prefibrotic to a fibrotic stage [1].

The patient was a 14 year-old-girl with thrombocytemia and the following complete blood count: white blood cell = 8000/µL, hemoglobin = 10.2 g/dl and platelet = 1,200,000/µL and treatment with anagrilide was started for her. Two year later, she complained of fatigue and abdominal fullness. Imaging workup revealed an enlarged spleen in sonography measuring 166 × 70 mm. Complete blood count showed leukocytosis, anemia and thrombocytopenia with a leucoerythroblastic change in peripheral blood smear (white blood cell = 15,800/µL, hemoglobin = 9 g/dl, platelet = 110,000/µL). Subsequently, she underwent bone marrow biopsy which showed grade 2 reticulin fibrosis along with megakaryocytic and...

Notes

Compliance with Ethical Standards

Conflict of interest

Authors declares that he/she has no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from individual participant included in the study.

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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Moeinadin Safavi
    • 1
  • Atoosa Gharib
    • 1
    • 2
  • Mohammad Taghi Haghi Ashtiani
    • 1
  • Poorya Salajegheh
    • 3
  • Mohammad Vasei
    • 1
  1. 1.Molecular Pathology and Cytogenetics Section, Pathology Department, Children’S Medical CenterTehran University of Medical SciencesTehranIran
  2. 2.Pathology Department, Shahid Modarres HospitalShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Pediatric Hematology-Oncology Ward, Afzalipoor HospitalKerman University of Medical SciencesKermanIran

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