Spurious Leukocyte Counts and an Abnormal Histogram Pattern Due to Fibrin Clumps
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Spuriously low or high automated WBC counts seen in laboratory practice can cause diagnostic and therapeutic dilemma. WBC histograms and scatterplots may have clues to the presence of an abnormal WBC population or interfering substances [1, 2]. We present a series of 14 patients in whom the automated WBC count was spuriously elevated due to interference by fibrin clumps. These patients were undergoing treatment for various hematological disorders (9 patients were chemotherapy and 5 patients were post bone marrow transplant).
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Conflict of interest
The author declares that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. No patient/subject identifying information has been disclosed in the manuscript. No patient/subject intervention was done and the subjects were not exposed to any risks during the study.
Since the study involved a retrospective review of data only from routine testing offered by the laboratory, separate informed consent was not taken for the study. Repeat sampling was done as part of routine protocol in case of suspected pre- analytic problem. “For this type of study formal consent is not required.”
- 1.Bain BJ (ed) (2002) Detecting erroneous blood counts. In: Blood cells: a practical guide, 3rd edn. Blackwell Science, London, pp 155–74Google Scholar
- 3.Geneviève F, Godon A, Marteau-Tessier A, Zandecki M (2012) Automated hematology analysers and spurious counts part 2. Leukocyte count and differential. Ann Biol Clin (Paris) 70:141–154Google Scholar
- 4.Maeda K, Pohlad R (1980) Pseudoleukocytosis due to fibrin strands. Am J Clin Pathol 74:497Google Scholar