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Diffuse Large B-Cell Lymphoma: A Rare Cause of Lung Consolidation

  • Aditya Jandial
  • Kundan Mishra
  • Pranab Dey
  • Deepak Goni
  • Mohd Umair
  • Deepesh Lad
  • Gaurav Prakash
  • Alka Khadwal
  • Neelam Varma
  • Pankaj Malhotra
Correspondence

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the commonest sub-type of non-Hodgkin lymphoma. However, lung consolidation is a rare presentation of DLBCL. Moreover, in view of poor general condition, it poses clinical dilemma of when to start chemotherapy and whether chemotherapy should be given at full dose or truncated doses till improvement in general condition. A 48-years-old lady was admitted with complaints of non-productive cough for 2 months duration. She was febrile and hypoxemic requiring oxygen supplementation. She had bilateral axillary lymphadenopathy, and bronchial breath sounds on chest auscultation. Chest X-ray showed non-homogenous opacities involving bilateral lower zones. A diagnosis of DLBCL was confirmed on lymph node biopsy and Immunohistochemistry. She received chemotherapy, following which a gradual, improvement in her breathlessness and cough was noted over ensuing week and she got discharged from the hospital and received rest of her chemotherapy on outpatient basis. In a case of DLBCL with lung consolidation, a high index of suspicion can clinch the diagnosis of secondary lymphomatous involvement. Presence of respiratory failure at presentation doesn’t necessarily warrants truncation of chemotherapy doses.

Keywords

Lymphoma Pneumonia Infection Emergency medicine Chemotherpy Imaging 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed Consent

Informed signed written consent was taken from the patient involved.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Human and Animals Rights

No animals were involved in the study.

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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Department of Internal MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of HistopathologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  3. 3.Department of HematologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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