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Relationship Between Haemostasis Parameters and Anxiety Under Examination Stress: A Pilot Study

  • Renad Ibrahimovich Zhdanov
  • Roman Vladimirovich Kupriyanov
  • Svetlana Igorevna Zhdanova
  • Vladimir Georgievich Dvoenosov
Short Communication
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Abstract

This work aims to clarify how blood coagulation parameters reflect mild stress response in males and females. Healthy student volunteers of both sexes were used in this pilot study. A new global sensitive assay of haemostasis, spatial thrombodynamics, along with conventional coagulometry approach were used to evaluate of blood coagulation parameters. Psychodiagnostics scales (according to Spielberger and Taylor) are employed to evaluate anxiety as stress-induced response. We have selected exam stress, which despite being a mild stressor may nevertheless cause somatic disorders. We provide the first evidence of a statistically significant increase in initial clot growth velocity in women, but not men, in response to exam stress. The exam situation produces higher situational anxiety in female volunteers, and so they express remarkable stress-induced haemostatic responses, including plasma- and platelet-based changes. In contrast, male volunteers do not express pronounced stress-induced changes in haemostasis, and only display a decrease in plateletcrit value and an increase in prothrombin time. Mild form of stress (exam) induces changes in some blood coagulation parameters. A statistically significant remarkable increase in Vinit value and some other plasma- and platelet-based parameters has been seen in female students (but not male ones) under exam stress.

Keywords

Haemostasis Blood coagulation Anxiety Gender Stress Thrombodynamics 

Abbreviations

Vinit

The initial velocity of induced thrombosis

Vsteady

The steady velocity of induced thrombosis

dSpeed

The difference between the initial and steady velocity of induced thrombosis

PT

Prothrombin time

INR

International normalized ratio

APTT

Activated partial thromboplastin time

PLT

Absolute number of platelets

MPV

The average platelets’ volume

PCT

Thrombocrit

STAI

State-trait anxiety inventory

TMAS

Teilor’s Manifest Anxiety Scale

Notes

Acknowledgements

The authors are grateful to Professor Dr. Fazly Ataullakhanov (Lomonosov Moscow State University and “HemaCore” Ltd) for the support with thrombodynamics studies and fruitful discussions. The work was supported and 2016-2018 Grant of Russian Institute of Advanced Study at the Moscow State Pedagogical University (to R.V.K.).

Funding

This work was funded by the subsidy allocated by the Russian Ministry of Education and Science, Grant # 19.9777.2017/8.9 to Kazan Federal University for the state assignment in the sphere of scientific activities.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards approved by the Local Ethics Committee of the Kazan State Medical University (6.21.06.18) and with the 1964 Helsinki declaration and its later amendments.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.“Healthy Food” Open Laboratory, Institute of Fundamental Medicine and BiologyKazan (Volga Region) Federal UniversityKazanRussian Federation
  2. 2.Russin Institute for Advanced StudyMoscow State Pedagogical UniversityMoscowRussian Federation
  3. 3.Chair of Social Work, Pedagogy and PsychologyKazan National Research Technological UniversityKazanRussian Federation
  4. 4.Chair of PediatryKazan State Medical UniversityKazanRussian Federation

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