Passenger Lymphocyte Syndrome Following Minor ABO Mismatch Liver Transplantation

  • Deepti SachanEmail author
  • Suryatapa Saha
  • Srinivas M. Reddy
  • Mohamed Rela

Dear Editor,

Non-ABO identical liver transplantation (LT) is in growing trend in India due to limited availability of organ donors and the growing number of patients awaiting orthotopic liver transplantation. Recipients of minor ABO mismatched organ transplantation may experience delayed hemolysis mediated by donor lymphocytes contained in the graft. Donor lymphocytes produce iso-agglutinins capable of destroying the recipient’s red cells, resulting in varying degree of hemolysis known as passenger lymphocyte syndrome (PLS) [1]. PLS is not an uncommon cause of anemia in non-ABO identical LT but often goes undiagnosed and not yet reported in India in ABO mismatch LT.

We present a case of 48 years old male, AB positive, with ethanol related end stage liver disease who underwent live donor liver transplant from a O positive donor without any intraoperative complications. He had history of multiple transfusions in past 2 years during episodes of gastrointestinal bleeds but no history of...


Compliance with Ethical Standards

Ethical Approval

All procedures were in accordance to ethical standards. Informed consent was taken from the patient before blood transfusions.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Department of Transfusion MedicineGleneagles Global Health CityChennaiIndia
  2. 2.HPB and Liver Surgery, Institute of Liver Disease and TransplantationGleneagles Global Health CityChennaiIndia

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