Rapid Onset Anemia in Chronic Myeloid Leukemia Due to Red Cell Agglutination: A Rare Occurrence

  • Shikha Garg
  • Vinod Sharma
  • Rajive Kumar
  • Lalit Kumar
  • Anita ChopraEmail author


Red cell agglutination Chronic myeloid leukemia Cold agglutinins 


Compliance with ethical standards

Ethical Approval

Peripheral blood smear, bone marrow examination and flow cytometric analysis was done as part of routine diagnostic work up. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


  1. 1.
    Diehl LF, Ketchum LH (1998) Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia. Semin Oncol 25:80–97PubMedGoogle Scholar
  2. 2.
    Crisp D, Pruzanski W (1982) B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins). Am J Med 72:915–922CrossRefGoogle Scholar
  3. 3.
    Hodgson K, Ferrer G, Montserrat E, Moreno C (2011) Chronic lymphocytic leukemia and autoimmunity: a systematic review. Haematologica 96:752–761CrossRefGoogle Scholar
  4. 4.
    Maldonado NI, Haddock J, Perez-Santiago E (1967) Autoimmune hemolytic anemia in chronic granulocytic leukemia. Blood 30:518–521PubMedGoogle Scholar
  5. 5.
    Chen FE, Owen I, Savage D, Roberts I, Apperley J (1997) Late onset haemolysis and red cell autoimmunisation after allogeneic bone marrow transplant. Bone Marrow Transplant 19:491–495CrossRefGoogle Scholar
  6. 6.
    Steegmann JL, Requena MJ, Martín-Regueira P, De La Cámara R, Casado F (2003) High incidence of autoimmune alterations in chronic myeloid leukemia patients treated with interferon-α. Am J Hematol 72(3):170–176CrossRefGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Shikha Garg
    • 1
  • Vinod Sharma
    • 2
  • Rajive Kumar
    • 1
  • Lalit Kumar
    • 2
  • Anita Chopra
    • 1
    Email author
  1. 1.Laboratory Oncology Unit, Dr. BRA-IRCHAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Medical Oncology Unit, Dr. BRA-IRCHAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations