Prevalence of Chromosome 7 Abnormalities in Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Single Center Study and Brief Literature Review

  • Ruchi Gupta
  • Shivangi Harankhedkar
  • Khaliqur RahmanEmail author
  • Manish K. Singh
  • Dinesh Chandra
  • Navkirti Mittal
  • Anshul Gupta
  • Soniya Nityanand
Original Article


Chromosome 7 abnormalities in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) heralds a poor prognosis. However its prevalence, morphological characteristics and clinical impact in MDS and AML in Indian subcontinent is sparsely reported. This was an observational cross-sectional study performed to evaluate the clinico-pathological profiles of MDS/AML patients with chromosome 7 abnormalities over a period of 4 years. 724 cases of MDS (n = 150) and AML (n = 574) were evaluated. Abnormal karyotype was detected in 49% (43/88) patients of MDS and 44% (127/289) cases of AML. Chromosome 7 abnormalities were detected in 18% cases of MDS (16/88) and 6.5% (19/289) cases of AML. Sole chromosome 7 abnormalities were detected in 5.7% (5/88) and 2.7% (8/289) and in adjunct to complex abnormalities in 7.9 and 3.1% cases of MDS and AML respectively. Morphologically, dyserythropoiesis, dysmyelopoiesis and eosinophilia were seen in 100, 66 and 56% cases of MDS and 38, 40 and 21% cases of AML. Majority of the patients had an aggressive natural course and outcome was dismal. Chromosome 7 abnormalities are strongly associated with the presence of morphological dysplasia and eosinophilia, irrespective of the type of aberration. It is invariably associated with very poor outcome.


MDS AML Chromosome 7 Morphology Cytogenetics 


Compliance with Ethical Standards

Conflict of interest


Ethical Standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Ruchi Gupta
    • 1
  • Shivangi Harankhedkar
    • 1
  • Khaliqur Rahman
    • 1
    Email author
  • Manish K. Singh
    • 1
  • Dinesh Chandra
    • 1
  • Navkirti Mittal
    • 1
  • Anshul Gupta
    • 1
  • Soniya Nityanand
    • 1
  1. 1.Department of Hematology, I BlockSanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS)LucknowIndia

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