Comparative efficacy in red blood cell exchange transfusions with different apheresis machines in patients with sickle cell disease

  • Nurhilal BuyukkurtEmail author
  • Ilknur Kozanoğlu
  • Asli Pan Korur
  • Suheyl Asma
  • Mahmut Yeral
  • Soner Solmaz
  • Fatih Kandemir
  • Cigdem Gereklioglu
  • Cagla Sariturk
  • Can Boga
  • Hakan Ozdogu
Original Article


The purpose of this study is to compare the efficacy and side effects of two red blood cell exchange (RBCX) transfusion systems in sickle cell disease (SCD). The data is collected retrospectively from the January 2010 to March 2015. 447 RBCX transfusions were performed to 165 patients. Side effects, clinical and technical efficacy were compared in between procedures with Cobe Spectra (CS) and Spectra Optia (SO) systems. Furthermore a subgroup analyses was performed for 40 patients who had RBCX transfusions with both system at least two times. Vasoocclusive crises, preoperative period and foot ulcers (49.6, 13, and 15.2% respectively) were the common indications of RBCX transfusion. While the levels of post-RBCX HbS and the actual fraction of cells remaining (FCRa) were found significantly higher in the SO compared to CS system (p = 0.018 and p = 0.016 respectively), the rate of targeted hemoglobin S (HbS) levels (< 30%) were same in both. The length of procedure and replacement volume were significantly lower in SO compared to CS system (p = 0.025 and 0.044 respectively). Subgroup analyses of 40 patients did not reveal any statistically significant differences regarding post-procedure HbS levels, FCRa levels, replacement volume and procedure duration. The inter-rater correlation coefficient for FCRa was calculated to be 0.82. Serious adverse reactions were not observed from either system. Both systems are efficiently achieved the targeted post-procedure HbS level. The recently introduced SO apheresis system is as effective and safe as the CS system, which has been used for all indications of SCD for years.


Sickle cell disease Red blood cell exchange Cobe Spectra Spectra Optia 



We thank to the apheresis unit staff for their cooperation.


This study was approved by the Institutional Medical and Health Sciences Experimental/Clinical Research Principles and Research Committee (Project No: KA15/148).

Compliance with Ethical Standards

Conflicts of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2017

Authors and Affiliations

  • Nurhilal Buyukkurt
    • 1
    Email author
  • Ilknur Kozanoğlu
    • 2
  • Asli Pan Korur
    • 3
  • Suheyl Asma
    • 3
  • Mahmut Yeral
    • 1
  • Soner Solmaz
    • 1
  • Fatih Kandemir
    • 1
  • Cigdem Gereklioglu
    • 3
  • Cagla Sariturk
    • 4
  • Can Boga
    • 1
  • Hakan Ozdogu
    • 1
  1. 1.Department of HematologyBaskent University School of MedicineAnkaraTurkey
  2. 2.Department of PhysiologyBaskent University School of MedicineAnkaraTurkey
  3. 3.Department of Family MedicineBaskent University School of MedicineAnkaraTurkey
  4. 4.Biostatistics Specialist, Adana Research and Training CenterBaskent UniversityAdanaTurkey

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