HbS/D-Punjab Disease: Report of 3 Cases from Sri Lanka

  • Krishan Hewa Thalagahage
  • Jayaweera Arachchige Asela Sampath Jayaweera
  • Widuranga Kumbukgolla
  • Nilukshi Perera
  • Ela Thalagahage
  • Jayani Kariyawasam
  • Vajira Dissanayake
Correspondence
  • 22 Downloads

Keywords

HbS/D- Punjab disease Hydroxyurea Clinical spectrum 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that there is no conflict of interest regarding the publication of this paper.

Ethical Approval

Was obtained from Ethics Review Committee, Faculty of Medicine and Allied Sciences, Rajarata University Saliyapura, Sri Lanka.

Informed Consent

Informed consent was obtained from guardians of all individual participants included in the study.

References

  1. 1.
    Vella F, Lehmann H (1974) Haemoglobin D Punjab (D Los Angeles). J Med Genet 11:341–342CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Barbara JB (2001) Sickle SS disease, haemoglobinopathy diagnosis, 2nd edn. Wiley-Blackwell Science, Oxford, pp 275–296Google Scholar
  3. 3.
    Patel S, Purohit P, Mashon RS, Dehury S, Meher S, Sahoo S et al (2014) The effect of hydroxyurea on compound heterozygotes for sickle cell-hemoglobin D-Punjab–a single centre experience in eastern India. Pediatr Blood Cancer 61(8):1341–1346. doi: 10.1002/pbc.25004 CrossRefPubMedGoogle Scholar
  4. 4.
    Steinberg MH (2009) Sickle cell SS. In: Steinberg MH, Forget BG, Higgset DR (eds) Disorders of hemoglobin: genetics, pathophysiology, clinical management, 2nd edn. Cambridge University Press, CambridgeCrossRefGoogle Scholar
  5. 5.
    Alsultan A, Alabdulaali MK, Griffin PJ, AlSuliman AM, Ghabbour HA, Sebastiani P et al (2014) Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab–Indian haplotype is not benign. Br J Haematol 64(4):597–604. doi: 10.1111/bjh.12650 CrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2017

Authors and Affiliations

  • Krishan Hewa Thalagahage
    • 1
  • Jayaweera Arachchige Asela Sampath Jayaweera
    • 2
  • Widuranga Kumbukgolla
    • 3
  • Nilukshi Perera
    • 4
  • Ela Thalagahage
    • 4
  • Jayani Kariyawasam
    • 5
  • Vajira Dissanayake
    • 5
    • 6
  1. 1.Department of PaediatricsTeaching Hospital AnuradahapuraAnuradhapuraSri Lanka
  2. 2.Department of Microbiology, Faculty of Medicine and Allied SciencesRajarata UniversitySaliyapuraSri Lanka
  3. 3.Department of Biochemistry, Faculty of Medicine and Allied SciencesRajarata UniversitySaliyapuraSri Lanka
  4. 4.Department of PathologyTeaching Hospital AnuradahapuraAnuradhapuraSri Lanka
  5. 5.Human Genetics UnitUniversity of ColomboColomboSri Lanka
  6. 6.Department of Anatomy, Faculty of MedicineUniversity of ColomboColomboSri Lanka

Personalised recommendations