Breast Cancer

, Volume 26, Issue 1, pp 113–124 | Cite as

Histogram analysis of quantitative pharmacokinetic parameters on DCE-MRI: correlations with prognostic factors and molecular subtypes in breast cancer

  • Ken NagasakaEmail author
  • Hiroko Satake
  • Satoko Ishigaki
  • Hisashi Kawai
  • Shinji Naganawa
Original Article



Breast cancer heterogeneity influences poor prognoses thorough therapy resistance. This study quantitatively evaluated intratumoral heterogeneity through a histogram analysis of dynamic contrast-enhanced MRI (DCE-MRI) pharmacokinetic parameters, and determined correlations with prognostic factors and molecular subtypes.


We retrospectively investigated 101 invasive ductal breast cancers from 99 women who underwent preoperative DCE-MRI between July 2012 and November 2014. Pharmacokinetic parameters (Ktrans, kep, and ve) were obtained by the Tofts model. For each parameter, the mean, standard deviation, coefficient of variation, skewness, and kurtosis values of tumor were calculated, and prognostic factors and subtypes associations were assessed.


The mean of ve was lower in cancers with high Ki-67 than in cancers with low Ki-67 (P = 0.002). The coefficient of variation of ve was higher in cancers with estrogen receptor negativity than in cancers with estrogen receptor positivity (P < 0.001). The coefficient of variation of ve was also higher in cancers with high Ki-67 than in cancers with low Ki-67 (P < 0.001). The skewness of ve was higher in cancers with high nuclear grade than in cancers with low nuclear grade (P = 0.006). Triple-negative cancers showed higher ve coefficient of variation than did those with luminal A (P < 0.001) and B (P = 0.006).


Various ve parameters correlated with breast cancer prognostic factors and molecular subtypes.


Brest cancer Dynamic contrast-enhanced MRI Histogram analysis Pharmacokinetic modeling 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Japanese Breast Cancer Society 2018

Authors and Affiliations

  • Ken Nagasaka
    • 1
    Email author
  • Hiroko Satake
    • 1
  • Satoko Ishigaki
    • 1
  • Hisashi Kawai
    • 1
  • Shinji Naganawa
    • 1
  1. 1.Department of RadiologyNagoya University Graduate School of MedicineNagoyaJapan

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