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The Manaus Declaration: Current Situation of Histoplasmosis in the Americas, Report of the II Regional Meeting of the International Histoplasmosis Advocacy Group

  • Diego H. CaceresEmail author
  • Antoine Adenis
  • João Vicente Braga de Souza
  • Beatriz L. Gomez
  • Katia Santana Cruz
  • Alessandro C. Pasqualotto
  • Giovanni Ravasi
  • Freddy Perez
  • Tom Chiller
  • Marcus Vinicius Guimarares de Lacerda
  • Mathieu Nacher
  • The International Histoplasmosis Advocacy Group (iHAG)
Epidemiology of Fungal Infections (T Chiller and J Baddley, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Epidemiology of Fungal Infections

Abstract

Purpose of Review

The aim of this report is to summarize the conclusions of the II Regional Meeting on Histoplasmosis in the Americas held in Manaus, Brazil, on March 22–24, 2019.

Recent Findings

Persons living with advanced HIV are at high risk for developing histoplasmosis. Clinical signs and symptoms of this disease are often non-specific, making it difficult to establish a diagnosis. Although with the recent technological advances, in vitro diagnostics and medicines for histoplasmosis are often not available in many regions around the world. In addition, histoplasmosis is often not included in HIV care and treatment programs, resulting in inadequate health system planning and missed opportunities to save lives.

Summary

The II Regional Meeting on Histoplasmosis in the Americas gathered a multidisciplinary audience. Developed recommendations to be included in the WHO guidelines for diagnosis and treatment of histoplasmosis in advanced HIV were the product of this meeting, and guidelines are aimed to be published in early 2020.

Keywords

Histoplasma Histoplasmosis Diagnosis Treatment Guidelines AIDS 

Notes

Acknowledgments

We want to thank all the International Histoplasmosis Advocacy Group (iHAG) members: https://docs.google.com/spreadsheets/d/189W6gMfVb2zW5StAW2U2AbwVwGhls8bkAc7npZgNdC8/edit?ts=5d6d4758#gid=474498568. We also want to thank Eduardo Serrão for the meeting logistics and Pooja Gandhi for editing the manuscript. iHAG 2019 co-sponsors: Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Instituto Nacional de Pesquisas da Amazôna (INPA), Global Action Fund for Fungal Infections (GAFFI), International Society for Human and Animal Mycology (ISHAM), Mycoses Study Group Education and Research Consortium (MSGERC), Centre d'Investigation Clinique INSERM, Centre Hospitalier de Cayenne, Universidad del Rosario, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), and Santa Casa de Misericórdia de Porto Alegre.

Compliance with Ethical Standards

Conflict of Interest

The findings and the conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2019

Authors and Affiliations

  • Diego H. Caceres
    • 1
    Email author
  • Antoine Adenis
    • 2
  • João Vicente Braga de Souza
    • 3
  • Beatriz L. Gomez
    • 4
  • Katia Santana Cruz
    • 5
  • Alessandro C. Pasqualotto
    • 6
  • Giovanni Ravasi
    • 7
  • Freddy Perez
    • 7
  • Tom Chiller
    • 1
  • Marcus Vinicius Guimarares de Lacerda
    • 8
    • 9
  • Mathieu Nacher
    • 3
  • The International Histoplasmosis Advocacy Group (iHAG)
  1. 1.Centers for Disease Control and Prevention, Mycotic Diseases BranchAtlantaUSA
  2. 2.Centre d’Investigation Clinique Antilles Guyane, Inserm CIC1424, Centre Hospitalier de CayenneCayenneFrench Guiana
  3. 3.Instituto Nacional de Pesquisas da Amazônia, Coordenação de Sociedade, ambiente e saúde, Laboratório de MicologiaManausBrazil
  4. 4.Studies in Translational Microbiology and Emerging Diseases (MICROS) Research Group, School of Medicine and Health SciencesUniversidad del RosarioBogotaColombia
  5. 5.Medical Mycology LaboratoryTropical Medicine Foundation Dr. Heitor Vieira DouradoManausBrazil
  6. 6.Universidade Federal de Ciências da Saúde Porto Alegre, and Santa Casa de misericórdia de Porto AlegrePorto AlegreBrazil
  7. 7.HIV, Hepatitis, Tuberculosis and STI UnitPan American Health OrganizationWashingtonUSA
  8. 8.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD)ManausBrazil
  9. 9.Fundação Oswaldo Cruz, Instituto Leônidas e Maria Deane (FIOCRUZ-Amazonas)ManausBrazil

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