Anti-varicella-zoster virus activity of cephalotaxine esters in vitro
- 37 Downloads
Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for treatment of chronic myelogenous leukemia. In addition to antileukemic activity, HT and HHT are reported to possess potent antiviral activity. In this study, we investigated the effects of HT and HHT on replication of varicella-zoster virus (VZV) in vitro. HT and HHT, but not their biologically inactive parental alkaloid cephalotaxine (CET), significantly inhibited replication of recombinant VZV-pOka luciferase. Furthermore, HT and HHT, but not CET, strongly induced down-regulation of VZV lytic genes and exerted potent antiviral effects against a VZV clinical isolate. The collective data support the utility of HT and HHT as effective antiviral candidates for treatment of VZV-associated diseases.
Keywordsvaricella zoster virus antiviral harringtonine homoharringtonine
Unable to display preview. Download preview PDF.
- Arvin, A. and Gilden, D. 2013. Varicella-zoster virus, pp. 2015–2057. In Knipe, D.M. and Howley, P.M. (eds.), Fields virology, Philadelphia (Pennsylvania): Lippincott Williams & Wilkins.Google Scholar
- Huang, M.T. 1975. Harringtonine, an inhibitor of initiation of protein biosynthesis. Mol. Pharmacol. 11, 511–519.Google Scholar
- Zhou, D.C., Zittoun, R., and Marie, J.P. 1995. Homoharringtonine: An effective new natural product in cancer chemotherapy. Bull. Cancer 82, 987–995.Google Scholar