Nano Research

, Volume 12, Issue 2, pp 247–264 | Cite as

Graphene-based nanomaterials in biosystems

  • Na Lu
  • Liqian Wang
  • Min Lv
  • Zisheng TangEmail author
  • Chunhai FanEmail author
Review Article


Graphene-based nanomaterials have emerged as a novel type of materials with exceptional physicochemical properties and numerous applications in various areas. In this review, we summarize recent advances in studying interactions between graphene and biosystems. We first provide a brief introduction on graphene and its derivatives, and then discuss on the toxicology and biocompatibility of graphene, including the extracellular interactions between graphene and biomacromolecules, cellular studies of graphene, and in vivo toxicological effects. Next, we focus on various graphene-based practical applications in antibacterial materials, wound addressing, drug delivery, and water purification. We finally present perspectives on challenges and future developments in these exciting fields.


graphene-based nanomaterials toxicology and biocompatibility biomacromolecules cells living entities applications 


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This work was financially supported by the National Key Research and Development Program (No. 2016YFA0201200), the Shanghai Municipal Natural Science Foundation (No. 17ZR1412100), the Key Laboratory of Interfacial Physics and Technology, the Chinese Academy of Sciences (No. CASKL-IPT1603), the Talent Program of Shanghai University of Engineering Science, the Startup Foundation for Doctors of Shanghai University of Engineering Science, and the National Natural Science Foundation of China (Nos. 81870749, 21373260, 31470960 and 51375294).


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Copyright information

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Materials EngineeringShanghai University of Engineering ScienceShanghaiChina
  2. 2.Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghaiChina
  3. 3.Department of Endodontics, Shanghai Ninth People’s Hospital, College of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina
  4. 4.National Clinical Research Center of Oral DiseasesShanghaiChina
  5. 5.Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of StomatologyShanghaiChina
  6. 6.School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of MedicineShanghai Jiao Tong UniversityShanghaiChina

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