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The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain

  • Seong-Eun Lee
  • Yunjong Lee
  • Gum Hwa LeeEmail author
Review

Abstract

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter that is required for the control of synaptic excitation/inhibition and neural oscillation. GABA is synthesized by glutamic acid decarboxylases (GADs) that are widely distributed and localized to axon terminals of inhibitory neurons as well as to the soma and, to a lesser extent, dendrites. The expression and activity of GADs is highly correlated with GABA levels and subsequent GABAergic neurotransmission at the inhibitory synapse. Dysregulation of GADs has been implicated in various neurological disorders including epilepsy and schizophrenia. Two isoforms of GADs, GAD67 and GAD65, are expressed from separate genes and have different regulatory processes and molecular properties. This review focuses on the recent advances in understanding the structure of GAD, its transcriptional regulation and post-transcriptional modifications in the central nervous system. This may provide insights into the pathological mechanisms underlying neurological diseases that are associated with GAD dysfunction.

Keywords

Glutamic acid decarboxylase GABA Neurotransmission Inhibitory neuron Synaptic plasticity 

Notes

Acknowledgements

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF2018R1D1A1B07043710).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

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© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.College of PharmacyChosun UniversityGwangjuSouth Korea
  2. 2.Division of Pharmacology, Department of Molecular Cell BiologySungkyunkwan University School of MedicineSuwonSouth Korea

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