Preventive approach for overcoming dementia

  • HeeYang Lee
  • DaWon Kim
  • Woogyeong Lee
  • Hye Yun KimEmail author
  • YoungSoo KimEmail author


Dementia is used as a general term to describe chronic disorders of mental processes caused by the deterioration of cognitive functions to the extent that one’s ability to perform daily activities is impaired. Currently, age is known to be the main risk factor for dementia, suggesting that the risk of being diagnosed with dementia significantly increases later in one’s life. Therefore, there are two approaches one can take when confronting dementia: to cure it when it occurs in late adulthood or to prevent the onset of symptoms beforehand. Recently, the latter strategy of delaying and preventing Alzheimer’s disease, the most prevalent form and most studied type of dementia, through both pharmaceutical and nonpharmaceutical interventions is becoming increasingly recognized. In this review, we discuss studies conducted in various fields that addresses nonpharmaceutical lifestyle interventions, including diet, physical activity, cognitive stimulation, and social engagement, and their effects in preventing and inhibiting dementia.


Alzheimer’s disease Dementia Lifestyle interventions Nonpharmaceutical interventions Prevention 



This work was supported by National Research Foundation (Basic Science Research Program NRF-2018R1A6A1A03023718, NRF-2018R1D1A1B07048857 and Original Technology Research Program for Brain Science NRF-2018M3C7A1021858), and Yonsei University (Grant No. 2018-22-0022).

Compliance with ethical standards

Conflict of interest

All authors declared no conflict of interest.


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© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Integrated Science and Engineering DivisionYonsei UniversityIncheonRepublic of Korea
  2. 2.Department of PharmacyYonsei UniversityIncheonRepublic of Korea
  3. 3.Yonsei Institute of Pharmaceutical SciencesYonsei UniversityIncheonRepublic of Korea

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