In vivo imaging for neurovascular disease research

  • Jin-Hui Yoon
  • Yong JeongEmail author


Connections between various cell types in the brain enable cognitive function. The neurovascular unit is a structure composed of different cell types that regulate neurovascular coupling, blood–brain barrier permeability, and other interactions with peripheral systems. The relationship among the components of the neurovascular unit is complex and difficult to study without the use of in vivo neurovascular disease imaging. In this review, we introduce principles and examples of various in vivo optical imaging techniques including laser Doppler flowmetry, laser speckle contrast imaging, intrinsic optical signal imaging, optical coherence tomography, and two-photon microscopy. Furthermore, we introduce recent advances of in vivo imaging and future directions for promoting neurovascular disease research.


In vivo imaging Neurovascular unit Neurodegenerative disease Dementia 



A special thanks to Ms. Heeyon Jeong who helped us to increase the quality of Fig. 1 and supplementary Fig. 1. This research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (2016M3C7A1913844).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

12272_2019_1128_MOESM1_ESM.docx (234 kb)
Supplementary material 1 (DOCX 234 kb)


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Copyright information

© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Department of Bio and Brain EngineeringKorea Advanced Institute of Science and Technology (KAIST)DaejeonRepublic of Korea
  2. 2.KI for Health Science and TechnologyKorea Advanced Institute of Science and Technology (KAIST)DaejeonRepublic of Korea

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