Non-glycosidic iridoids from the roots of Patrinia scabra and their nitric oxide production inhibitory effects

  • Da Hye Lee
  • Ji-Sun Shin
  • Jin Su Lee
  • Shin-Young Kang
  • Hee-Soo Han
  • Seung Mok Ryu
  • Kyung-Tae Lee
  • Dongho LeeEmail author
  • Dae Sik JangEmail author
Research Article


Phytochemical investigation on the 70% aqueous EtOH extract from the roots of Patrinia scabra led to the isolation and characterization of five new non-glycosidic iridoids, patriscabrins F–J (15), along with a known iridoid 11-ethoxyviburtinal (6). The structures of the new compounds 15 were determined by interpretation of spectroscopic data, particularly by 1D- and 2D-NMR and ECD studies. Thereafter, the isolates 16 were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. Of these, patriscabrin F (1) exhibited the most potent inhibitory effect with observed IC50 value of 14.1 μM. In addition, patriscabrin G (2) and 11-ethoxyviburtinal (6) showed IC50 values 24.6 and 35.5 μM, respectively.


Patrinia scabra Valerianaceae Iridoid Patriscabrin Nitric oxide 



This research was supported by a Grant from the Bio-Synergy Research Project (NRF-2015M3A9C4070483) of the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF), and by Basic Science Research Program through the NRF funded by the Ministry of Education (NRF-2016R1D1A1B03930222).

Compliance with ethical standards

Conflict of interest

There are no conflicts of interest of all authors with respect to this work.

Supplementary material

12272_2019_1117_MOESM1_ESM.docx (3.4 mb)
Supplementary material 1 (DOCX 3433kb)


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Copyright information

© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Department of Life and Nanopharmaceutical Sciences, Graduate SchoolKyung Hee UniversitySeoulRepublic of Korea
  2. 2.Department of Biosystems and Biotechnology, College of Life Sciences and BiotechnologyKorea UniversitySeoulRepublic of Korea

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