Cytotoxic isocoumarin derivatives from the mangrove endophytic fungus Aspergillus sp. HN15-5D
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Five isocoumarin derivatives including three new compounds, aspergisocoumrins A–C (1–3), together with two known analogues, 8-dihydroxyisocoumarin-3-carboxylic acid (4) and dichlorodiaportin (5) were obtained from the culture of the endophytic fungus Aspergillus sp. HN15-5D derived from the fresh leaves of the mangrove plant Acanthus ilicifolius. Their structures were elucidated using comprehensive spectroscopic methods. The double bond geometry of compounds 1 and 2 were assigned as E and Z on the basis of the distinct coupling constants, respectively. Compounds 1 and 2 showed cytotoxicity against MDA-MB-435 with IC50 values of 5.08 ± 0.88 and 4.98 ± 0.74 μM, respectively.
KeywordsIsocoumarins Cytotoxicity Aspergillus sp. Mangrove endophytic fungus
We thank the National Natural Science Foundation of China (21472251, 41404134), the Science & Technology Plan Project of Guangdong Province of China (2013B021100021), Natural Science Program of Guangdong Province (2016A030313588) and the Key Project of Natural Science Foundation of Guangdong Province (2016A040403091) for generous support.
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Conflict of interest
The authors declare no conflict of interest.
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