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Archives of Pharmacal Research

, Volume 41, Issue 1, pp 30–34 | Cite as

Saroclazines A–C, thio-diketopiperazines from mangrove-derived fungi Sarocladium kiliense HDN11-84

  • Feng Li
  • Wenqiang Guo
  • Li Wu
  • Tianjiao Zhu
  • Qianqun Gu
  • Dehai Li
  • Qian CheEmail author
Research Article

Abstract

Three new diketopiperazine derivatives (DKPs), saroclazines A–C (13) along with three known DKPs (46) were isolated from mangrove-derived fungi Sarocladium kiliense HDN11-84. Saroclazines A–B (1 and 2) possessed a free amide structure, which was first found in sulfur-containing aromatic DKPs. Their structures were elucidated by NMR, HRESIMS and X-ray. The cytotoxic activity of new compounds (13) was tested against HeLa cell lines, among which compound 2 showed an IC50 value of 4.2 µM.

Keywords

Fungi Mangrove Sarocladium kiliense Cytotoxic activity 

Notes

Acknowledgements

This work was financially supported by the Chinese National Natural Science Fund (21372208 and 21542001), Shandong Provincial Natural Science Fund for Distinguished Young Scholars (JQ201422), NSFC–Shandong Joint Fund for Marine Science Research Centers (U1606402), AoShan Talents Program Supported by Qingdao National Laboratory for Marine Science and Technology (2015ASTP-ES09) and Fundamental Research Funds for the Central Universities (201564026).

Supplementary material

12272_2017_961_MOESM1_ESM.docx (908 kb)
Supplementary material 1 (DOCX 907 kb)

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Copyright information

© The Pharmaceutical Society of Korea 2017

Authors and Affiliations

  1. 1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of ChinaQingdaoPeople’s Republic of China
  2. 2.Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and TechnologyQingdaoPeople’s Republic of China

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