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BIOspektrum

, Volume 25, Issue 6, pp 603–606 | Cite as

Assemblierung des CuA-Zentrums in bakterieller Cytochrom-Oxidase

  • Fabia Canonica
  • Rudi Glockshuber
  • Hauke HenneckeEmail author
Wissenschaft Metallproteinbiogenese
  • 23 Downloads

Abstract

The CuA cofactor in cytochrome oxidase of mitochondria and many aerobic prokaryotes is a di-copper metal center that catalyzes one-electron transfer from cytochrome c to the oxygen-reducing active site. How the two copper ions are brought together for assembly of CuA is reported here. A thioredoxin-like disulfide reductase and two dedicated metal-lochaperones, one for Cu2+ and one for Cu1+, cooperate in this process. Copper insertion into cytochrome oxidase proceeds by a previously unknown mechanism.

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Copyright information

© Springer-Verlag 2019

Authors and Affiliations

  • Fabia Canonica
    • 1
    • 2
  • Rudi Glockshuber
    • 1
    • 2
  • Hauke Hennecke
    • 2
    Email author
  1. 1.Institut für Molekularbiologie und BiophysikETH ZürichZürichSchweiz
  2. 2.Institut für MikrobiologieETH ZürichZürichSchweiz

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