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BIOspektrum

, Volume 24, Issue 6, pp 604–607 | Cite as

Schutzmechanismen der Gen-Umwelt-Achse in Morbus Parkinson

  • Alexander Kilzheimer
  • Julia Schulze-Hentrich
Wissenschaft · Special: PCR & qPCR Neurodegeneration
  • 7 Downloads

Abstract

Environmental factors harbor capacity to modulate onset and progression of Parkinson’s disease. To identify genes transducing beneficial environmental cues into the genomic program, we examined environment-induced changes in hippocampal gene activity of mice overexpressing human SNCA, an aetiological key gene. Our results point to an environment-inducible gene network that prevented SNCA-dependent disturbances in gene activity and might aid in identifying novel therapeutic opportunities.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Institut für Medizinische Genetik Und Angewandte GenomikUniversität TübingenTübingenDeutschland
  2. 2.Institut für Medizinische Genetik und Angewandte GenomikUniversitätsklinikum TübingenTübingenDeutschland

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