, Volume 24, Issue 6, pp 590–592 | Cite as

TGFβ in der Entwicklung und Metastasierung von Karzinomen

  • Andre MenkeEmail author
  • Klaudia GiehlEmail author
Wissenschaft Zellmigration


Depending on conditions and tumor stage, the transforming growth factor β (TGFβ) can act either as tumor suppressor or as tumor promoter. One process by which TGFβ contributes to metastatic events is the epithelial to mesenchymal transition (EMT). This process results in de - differentiation of tumor cells, gain of migratory capability and increase of tumor cell survival in particular of detached tumor cells. In the last years multiple mechanisms have been described by which TGFβ mediates EMT in a variety of tumor entities.


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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Molekulare Onkologie Solider Tumore, Klinik für Innere MedizinUniversität GießenGießenDeutschland
  2. 2.Signaltransduktion Zellulärer Motilität, Klinik für Innere MedizinUniversität GießenGießenDeutschland

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