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Gender-Specific Predictive Markers of Poor Prognosis for Patients with Acute Myocardial Infarction During a 6-Month Follow-up

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Mounting evidence indicates the impact of gender difference on the assessment, treatment, and outcome of patients with acute myocardial infarction (AMI). However, gender-specific prognostic markers of AMI are still lacking. The present study aimed to investigate gender-specific markers of poor prognosis (all-cause mortality or readmission) in a cohort of AMI patients followed up for 6 months. Compared with males (n = 157), females (n = 40) were older and more frequent with previous medical history of hypertension and diabetes mellitus. During the 6-month follow-up, BUN ≥ 7.73 mM, myoglobin ≥ 705.8 ng/mL, and Killip classification 2–4 were identified as the independent predictors of poor prognosis for male AMI patients, while D-dimer ≥ 0.43 mg/L as an independent predictor of poor prognosis in female AMI patients. In conclusion, our data suggest that prognostic markers for AMI patients may differ according to genders. Gender-specific prognostic markers may be useful to guide the risk stratification, clinical therapy, and medications for AMI patients.

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Correspondence to Ming Luo.

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The authors declare that they have no conflict of interest.

Research Involving Human Participants

This study had enrolled 206 consecutive patients diagnosed and hospitalized for the first visit of AMI in Cardiology Department of Tongji Hospital affiliated to Tongji University (Shanghai, China) from October 2015 to August 2017. All patients were diagnosed according to Guidelines for the Diagnosis and Treatment of AMI in China. Patients with malignant tumor and/or uncontrolled systemic diseases including kidney diseases and renal dysfunction were excluded. The present study was approved by the independent Ethics Committee of Tongji Hospital affiliated to Tongji University (Shanghai, China). Each participant signed informed consent form at enrollment.

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Wang, P., Yao, J., Xie, Y. et al. Gender-Specific Predictive Markers of Poor Prognosis for Patients with Acute Myocardial Infarction During a 6-Month Follow-up. J. of Cardiovasc. Trans. Res. 13, 27–38 (2020). https://doi.org/10.1007/s12265-019-09946-6

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  • Gender
  • Myocardial infarction
  • Prognostic marker