Novel Embolic Protection Device: a Feasibility Study
Stroke is ranked as the second leading cause of death worldwide. Ischemic stroke commonly results from emboli that originate in the heart among high-risk patients, such as those who develop atrial fibrillation. Yet, treatment is currently limited to anticoagulants, which may be associated with life-threatening bleeding. Our aim was to develop an alternative, device-based approach for continuous stroke prevention in high-risk patients. To this end, a novel endovascular tubular mesh was designed to be implanted in the aortic arch and to reroute emboli away from critical cerebral arteries. The feasibility of this approach as a means of ischemic stroke prevention was tested in vitro. The simulated cerebral perfusion pressures were not affected by the device. Also, the device efficiently diverted clinically meaningful embolic particles away from the cerebral circulation. It is proposed that this device could be used to reroute cardio-emboli away from intracranial vessels as a means of stroke prevention among patients for which anticoagulants are contraindicated.
KeywordsStroke Embolic protection Anticoagulants Left atrial appendage occlusion
Internal carotid artery
Large vessel occlusions
Left atrial appendage occlusion
Middle cerebral artery
We thank Faye Schreiber for editorial assistance. Also, we wish to thank Ohad Shaplan (Pangolin, Inc.) and Uri Shpolanski (Physiomodels, Inc.) for their help with setting up the experimental systems and data collection, respectively.
This study was funded by the Israel Innovation Authority.
Compliance with Ethical Standards
Conflict of Interests
The study was conducted by InVatin Technologies, Ltd. InVatin Technologies, Ltd was founded by Udi Nussinovitch, MD, PhD. UN and ER are employees of InVatin Technologies, Ltd. DB is a consultant for InVatin Technologies, Ltd.
This article does not include any studies with human participants or animals performed by any of the authors.
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