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Left Ventricular Mass in Hypertrophic Cardiomyopathy Assessed by 2D-Echocardiography: Validation with Magnetic Resonance Imaging

  • Maria Angela LosiEmail author
  • Massimo Imbriaco
  • Grazia Canciello
  • Filomena Pacelli
  • Carlo Di Nardo
  • Raffaella Lombardi
  • Raffaele Izzo
  • Costantino Mancusi
  • Andrea Ponsiglione
  • Serena Dell’Aversana
  • Alberto Cuocolo
  • Giovanni de Simone
  • Bruno Trimarco
  • Emanuele Barbato
Original Article
  • 31 Downloads

Abstract

We aim to validate echocardiographic left ventricular (LV) mass (echoLVM) in sixty-one patients with hypertrophic cardiomyopathy (HCM), using cardiac magnetic resonance measures (cmrLVM) as gold standard. cmrLVM was calculated using LV short-axis images, from base to apex, whereas echoLVM by LV epicardial minus LV endocardial volumes in 4 and 2 chamber views, using Simpson disk summation; trabeculae and papillary muscle were excluded in both cmrLVM and echoLVM. cmrLVM and echoLVM were not different by paired t test (145 ± 66 vs 147 ± 61; p = 0.240), and their correlation was good (r = 0.977; p < 0.0001). Intraclass correlation demonstrated reliability of echoLVM with cmrLVM (ρ = 0.987; Cls = 0.978–0.992; p < 0.0001). LV end-diastolic volume was higher by CMR than that by echo (137 ± 33 vs 85 ± 28 mL, p < 0.0001), resulting in a lower mass/volume ratio (1.1 ± 0.4 vs 1.8 ± 0.8, p < 0.0001). EchoLVM may be determined in patients with HCM. However, mass/volume ratio is higher by echocardiography than that by CMR.

Keywords

Hypertrophic cardiomyopathy Left ventricular mass Cardiac magnetic resonance Echocardiography 

Notes

Compliance with Ethical Standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Maria Angela Losi
    • 1
    Email author
  • Massimo Imbriaco
    • 1
  • Grazia Canciello
    • 1
  • Filomena Pacelli
    • 1
  • Carlo Di Nardo
    • 1
  • Raffaella Lombardi
    • 1
  • Raffaele Izzo
    • 1
  • Costantino Mancusi
    • 1
  • Andrea Ponsiglione
    • 1
  • Serena Dell’Aversana
    • 1
  • Alberto Cuocolo
    • 1
  • Giovanni de Simone
    • 1
  • Bruno Trimarco
    • 1
  • Emanuele Barbato
    • 1
  1. 1.Department of Advanced Biomedical SciencesUniversity Federico II of NaplesNaplesItaly

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