Journal of Cardiovascular Translational Research

, Volume 11, Issue 6, pp 459–469 | Cite as

Effect of Long-Term Exercise Training on lncRNAs Expression in the Vascular Injury of Insulin Resistance

  • Suixin Liu
  • Fan Zheng
  • Ying CaiEmail author
  • Wenliang Zhang
  • Yaoshan Dun
Original Article


LncRNA microarray analysis was applied to investigate the exercise effect on the global differential expressions of lncRNA and mRNA in aorta endothelium in insulin resistance. Twenty-four male C57BL/6 J mice were randomly divided into three groups: control group (n = 8), high-fat diet group (n = 8), and high-fat diet plus exercise training group (n = 8). An lncRNA microarray analysis was applied to investigate the global differential expressions of lncRNA and mRNA in aorta endothelium among three groups and the results were further verified by qPCR. Hypergeometric distribution analysis was applied to reveal the possible signaling. Exercise might alleviate the vascular injury of IR via FR030200-Col3A1, FR402720-Rnd1, and FR030200/FR402720-Rnd3 signalings in cytoskeletal rearrangement pathway; E2F1-FR030200/FR402720-Nnat and FR030200/ FR402720-Fam46a signalings in anti-inflammation pathway. This study identified a panel of dysregulated lncRNAs and mRNAs that might serve as potential biomarkers relevant to the vascular injury in insulin resistance induced by high-fat diet.


lncRNA Insulin resistance Vascular injury Exercise 



This project was funded by the National Science Foundation for Young Scientists of China (grant number 81501955).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethical Approval

All institutional and national guidelines for the care and use of laboratory animals were followed and approved by the Central South University Institute Animal Care and Use Committee.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Suixin Liu
    • 1
  • Fan Zheng
    • 1
  • Ying Cai
    • 1
    Email author
  • Wenliang Zhang
    • 1
  • Yaoshan Dun
    • 1
  1. 1.Cardiac Rehabilitation Center of Rehabilitation Department, Xiangya HospitalCentral South UniversityChangshaPeople’s Republic of China

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