Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia
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Schizophrenia is a chronic and debilitating brain disorder, which has a strong genetic component with heritability ranging from 66% to 85% [1, 2]. Currently, antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia . Because of the severe side-effects of first-generation antipsychotics (FGAs), second-generation antipsychotics (SGAs) have become more widely used in the treatment of schizophrenia. However, due to differing clinical, demographic, environmental, and genetic factors, the treatment response to SGAs shows considerable differences among patients. Most SGAs are antagonists of dopamine D2 (DRD2) and serotonin 2A (5-HT2A) receptors. It has been reported that DRD2 and 5-HT2A receptors play critical roles in antipsychotic effects. Several studies have shown that polymorphisms of the DRD2 and 5-HT2A receptor genes are associated with the antipsychotic response in schizophrenia. However, findings remain inconsistent and even...
This work was supported by the National Basic Research Development Program (2016YFC0904300), the National Natural Science Foundation of China (81630030 and 81461168029), and the 1.3.5 Project for Disciplines of Excellence of West China Hospital, Sichuan University (ZY2016103 and ZY2016203), China.
Conflict of interest
All authors claim that there are no conflicts of interest.