NONO Regulates Cortical Neuronal Migration and Postnatal Neuronal Maturation
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The mammalian cerebral cortex, responsible for all higher-order brain functions, is organized into six layers of neurons that form distinct projections and connections within and outside the cortex. During cortical development, neural progenitor cells (NPCs) in the proliferative ventricular zone (VZ) and subventricular zone (SVZ) of the dorsal telencephalon produce projection neurons that migrate toward the pial surface to form the cortical plate (CP). New-born neurons adopt a multipolar morphology with dynamic morphological rearrangement within the SVZ and the lower intermediate zone (IZ). This multipolar stage ends when cells extend a dominant pia-directed leading process and transform to a characteristic bipolar morphology [1, 2, 3]. This process is known as the multipolar-to-bipolar transition. After migrating radially to their correct position in the CP, neurons further develop a dendritic arborization, the basis of synaptic connections [4, 5]. Disturbance of...
We thank Dr. Frank Polleux (Columbia University, USA) for providing pNeuroD1-GFP plasmid and Dr. Yang Chen (Peking University, China) for sharing GM130 antibody. We are grateful to members of the Shen laboratory (Tongji University, China) for suggestions and comments. This work was supported by the National Natural Science Foundation of China (31371093 and 31671068), the Tsinghua Center for Life Sciences, and Tongji Hospital and School of Life Sciences and Technology, Tongji University, China.
Conflict of interest
The authors declare that they have no conflict of interest in this work.
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