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Gut Microbiota and Short Chain Fatty Acids: Influence on the Autonomic Nervous System

  • Jessica Bruning
  • Andrew Chapp
  • Gregory A. Kaurala
  • Renjun Wang
  • Stephen Techtmann
  • Qing-Hui ChenEmail author
Insight

Reaching across multiple fields of focus, spanning from periodontistry to gastroenterology to neurobiology to behavior, interest in the influence of the microbiome in human physiology and pathology has risen over the past few decades. Microbiota co-exist in and on humans forming an evolutionarily symbiotic biological unit, a halobiont, in which disruptions in the relationship can occur through genomic alterations and mutations [1]. The human microbiome consists of bacteria, viruses, fungi, and protozoans that contribute 450 times more genes to this relationship and slightly outnumber human host cells [2, 3]. The bacteria in the gastrointestinal (GI) tract are of the most interest and exist within five phyla: Bacteroidetes, Firmicutes, Proteobacteria, Actinobacteria, and Verrucomicrobia. Within the Verrucomicrobia an interesting bacterium has emerged, Akkermansia muciniphila, a mucus-degrading bacterium that influences intestinal permeability [3, 4]. The composition of individual...

Notes

Acknowledgements

This insight was supported by Michigan Technological University Portage Health Foundation, America Heart Association (16PRE27780121) and National Natural Science Foundation of China (31871150).

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  • Jessica Bruning
    • 1
  • Andrew Chapp
    • 2
  • Gregory A. Kaurala
    • 3
  • Renjun Wang
    • 4
  • Stephen Techtmann
    • 3
  • Qing-Hui Chen
    • 1
    Email author
  1. 1.Department of Kinesiology and Integrative PhysiologyMichigan Technological UniversityHoughtonUSA
  2. 2.Department of NeuroscienceUniversity of MinnesotaMinneapolisUSA
  3. 3.Department of Biological ScienceMichigan Technological UniversityHoughtonUSA
  4. 4.Department of Biotechnology, School of Life ScienceJilin Normal UniversitySipingChina

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