Neuroscience Bulletin

, Volume 35, Issue 6, pp 1058–1072 | Cite as

Recent Advances in the Genetic Dissection of Neural Circuits in Drosophila

  • Chao GuoEmail author
  • Yufeng Pan
  • Zhefeng Gong


Nervous systems endow animals with cognition and behavior. To understand how nervous systems control behavior, neural circuits mediating distinct functions need to be identified and characterized. With superior genetic manipulability, Drosophila is a model organism at the leading edge of neural circuit analysis. We briefly introduce the state-of-the-art genetic tools that permit precise labeling of neurons and their interconnectivity and investigating what is happening in the brain of a behaving animal and manipulating neurons to determine how behaviors are affected. Brain-wide wiring diagrams, created by light and electron microscopy, bring neural circuit analysis to a new level and scale. Studies enabled by these tools advances our understanding of the nervous system in relation to cognition and behavior.


Drosophila Neural circuit Neuroanatomy Neurogenetics Systems neuroscience 



This review was supported by the National Natural Science Foundation of China (6531000063, 31571093, 31622028, 31471063, and 31671074), the Science Foundation of Jiangsu Province of China (BK20160025), and Fundamental Research Funds for the Central Universities, China (2242016R20028 and 2017FZA7003).

Conflict of interest

All authors claim that there are no conflicts of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Key Laboratory of Developmental Genes and Human Disease of the Ministry of Education of China, Institute of Life SciencesSoutheast UniversityNanjingChina
  2. 2.Department of Neurobiology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Key Laboratory of NeurobiologyZhejiang University School of MedicineHangzhouChina

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