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Neuroscience Bulletin

, Volume 35, Issue 5, pp 921–933 | Cite as

Dual Functions of Microglia in Ischemic Stroke

  • Chuan Qin
  • Luo-Qi Zhou
  • Xiao-Tong Ma
  • Zi-Wei Hu
  • Sheng Yang
  • Man Chen
  • Dale B. Bosco
  • Long-Jun WuEmail author
  • Dai-Shi TianEmail author
Review

Abstract

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However, increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes, and endothelial cells within the brain parenchyma and the neurovascular unit.

Keywords

Microglia Inflammation Ischemic stroke Signaling pathways 

Notes

Acknowledgements

This review was supported by the National Natural Science Foundation of China (81571132, 81873743, and 81801223), Fundamental Research Funds for the Central Universities, China (2017KFYXJJ107 and 2017KFYXJJ124), and the National Institutes of Health, USA (R01NS088627).

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  • Chuan Qin
    • 1
  • Luo-Qi Zhou
    • 1
  • Xiao-Tong Ma
    • 1
  • Zi-Wei Hu
    • 1
  • Sheng Yang
    • 1
  • Man Chen
    • 1
  • Dale B. Bosco
    • 2
  • Long-Jun Wu
    • 2
    Email author
  • Dai-Shi Tian
    • 1
    Email author
  1. 1.Department of Neurology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of NeurologyMayo ClinicRochesterUSA

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