Selective Targeting of Perirhinal Cortex Projection to Hippocampal CA1 Interneurons
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The perirhinal cortex (PER) is conceptually important in the recognition memory, especially in familiarity discrimination, whereas the hippocampus is important for association and recollection . This notion is known as the dual-process model of recognition memory. An alternative idea suggests that, like the hippocampus, the PER contributes to both familiarity and recollection , known for the unitary process model. Both models have made strong emphasis on a vital role of the PER and hippocampus in recognition memory, suggesting that they are highly interconnected. Indeed, previous animal studies using anterograde and retrograde tracers revealed direct anatomic projections from the PER to hippocampus in rodents and monkeys [3, 4, 5]. However, the latter projection is less prominent compared to that of PER to entorhinal cortex (EC) or that of EC to hippocampus. This may implicate that information flow from PER to hippocampus is primarily through an indirect path, where...
This work was supported by grants from the Beijing Municipal Science & Technology Commission (Z181100001518001) and the Interdisciplinary Research Funds of Beijing Normal University.
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