Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies
Recurrent complex visual hallucinations are a core clinical feature of dementia with Lewy bodies (DLB) and are typically well-formed, often consisting of figures, such as people or animals . Despite the profound impact upon patients and caregivers in DLB, the aetiopathology of visual hallucinations remains largely unknown. In this article we discuss the anatomy of the human visual system, hypotheses of the genesis of visual hallucinations in DLB, and imaging and neuropathological studies that have attempted to understand visual hallucinations on a functional and anatomical basis.
The Human Visual System
Human visual input comes from the eye, where light is transduced by the photoreceptors of the retina and transmitted along the optic nerve. Retinal ganglion cells, whose axons comprise the optic nerve, transmit a neural representation of the observed visual field to the lateral geniculate nucleus (LGN) of the thalamus, the primary subcortical relay centre between the...
DE is funded by Alzheimer’s Research UK. The funder had no role in production of the manuscript or the choice of when or where to publish.
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