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The Glutamatergic Postrhinal Cortex–Ventrolateral Orbitofrontal Cortex Pathway Regulates Spatial Memory Retrieval

  • Xinyang Qi
  • Zhanhong Jeff Du
  • Lin Zhu
  • Xuemei Liu
  • Hua Xu
  • Zheng Zhou
  • Cheng Zhong
  • Shijiang Li
  • Liping WangEmail author
  • Zhijun ZhangEmail author
Original Article
  • 94 Downloads

Abstract

A deficit in spatial memory has been taken as an early predictor of Alzheimer’s disease (AD) or mild cognitive impairment (MCI). The uncinate fasciculus (UF) is a long-range white-matter tract that connects the anterior temporal lobe with the orbitofrontal cortex (OFC) in primates. Previous studies have shown that the UF impairment associated with spatial memory deficits may be an important pathological change in aging and AD, but its exact role in spatial memory is not well understood. The pathway arising from the postrhinal cortex (POR) and projecting to the ventrolateral orbitofrontal cortex (vlOFC) performs most of the functions of the UF in rodents. Although the literature suggests an association between spatial memory and the regions connected by the POR–vlOFC pathway, the function of the pathway in spatial memory is relatively unknown. To further illuminate the function of the UF in spatial memory, we dissected the POR–vlOFC pathway in mice. We determined that the POR–vlOFC pathway is a glutamatergic structure, and that glutamatergic neurons in the POR regulate spatial memory retrieval. We also demonstrated that the POR–vlOFC pathway specifically transmits spatial information to participate in memory retrieval. These findings provide a deeper understanding of UF function and dysfunction related to disorders of memory, as in MCI and AD.

Keywords

Spatial memory Postrhinal cortex Ventrolateral orbitofrontal cortex Mild cognitive impairment Alzheimer’s disease 

Notes

Acknowledgements

This work was supported by the National Major Science and Technology Program of China (2016YFC1306700), the National Natural Science Foundation of China (81420108012, 81671046, 81425010 and 31630031), the Jiangsu Provincial Medical Program for Distinguished Scholars (2016006), and Postgraduate Research & Practice Innovation Program of Jiangsu Province (KYCX18_0167), China.

Conflict of interest

All authors declare that no competing interests exist.

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  • Xinyang Qi
    • 1
  • Zhanhong Jeff Du
    • 2
  • Lin Zhu
    • 1
  • Xuemei Liu
    • 2
  • Hua Xu
    • 1
  • Zheng Zhou
    • 2
  • Cheng Zhong
    • 2
  • Shijiang Li
    • 3
  • Liping Wang
    • 2
    Email author
  • Zhijun Zhang
    • 1
    • 2
    Email author
  1. 1.Department of Neurology, Affiliated ZhongDa Hospital, Institute of Neuropsychiatry, School of MedicineSoutheast UniversityNanjingChina
  2. 2.Shenzhen Key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences (CAS) Center for Excellence in Brain Science and Intelligence Technology, the Brain Cognition and Brain Disease Institute for Collaboration Research of the Shenzhen Institutes of Advanced Technology at the CAS and the McGovern Institute at Massachusetts Institute of TechnologyShenzhenChina
  3. 3.Department of BiophysicsMedical College of WisconsinMilwaukeeUSA

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