Orthostatic Intolerance and Coagulation Abnormalities: An Update
- 44 Downloads
Orthostatic intolerance (OI) is a series of clinical symptoms that develop during long-term standing in the upright position, with clinical manifestations of frequent, recurrent, or persistent dizziness, fatigue, and heart palpitations with or without syncope. These symptoms are relieved after changing to the supine posture . OI includes vasovagal syncope (VVS), postural tachycardia syndrome, and autonomic nervous dysfunction . The pathogenesis underlying the vasovagal response (VVR) is not well-defined, but is considered to involve changes in the autonomic system and vascular dysfunction [2, 3].
The notion of OI co-morbidity and its importance in chronic fatigue syndrome has gained increasing attention [4, 5]. Recent studies have suggested that the blood coagulation system is activated during orthostatic stress [6, 7]. Induction of VVR leads to changes in blood coagulation factors indicating a hypercoagulable state . Similar changes in the coagulation system have been...
- 1.Writing Committee Members, Shen WK, Sheldon RS, Benditt DG, Cohen MI, Forman DE, et al. ACC/AHA/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Heart Rhythm 2017, 14(8): e218–e254.Google Scholar
- 2.Chen L, Du JB. Advances in studies on orthostatic intolerance in childhood. Chin J Pediatr 2006, 44: 904.Google Scholar
- 3.Liao Y, Du JB. Intensive reading and interpretation of the guidelines for diagnosis of syncope in children. Chin J Pediatr 2010, 48: 262–265.Google Scholar
- 4.Liao Y, Zhang QY, Li HX, Wang YL, Liu P, Du JB. Co-morbidity of vasovagal syncope and postural tachycardia syndrome with allergic diseases in children. J Peking Univ 2017, 49: 783–788.Google Scholar
- 15.Crnošija L, Krbot Skorić M, Lovrić M, Junaković A, Miletić V, Alfirev RŠ, et al. Differences in neurohumoral and hemodynamic response to prolonged head-up tilt between patients with high and normal standing norepinephrine forms of postural orthostatic tachycardia syndrome. Auton Neurosci 2017, 205: 110–114.CrossRefGoogle Scholar
- 24.Wu X, Wang G, Feng J. Syncope as initial symptom for nephrotic syndrome: a case report. Int J Clin Exp Med 2015, 8: 16868–16870.Google Scholar