SUMOylation of Fragile X Mental Retardation Protein: A Critical Mechanism of FMRP-Mediated Neuronal Function
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Recently, Khayachi et al.  showed that fragile X mental retardation protein (FMRP) is an active substrate of the small ubiquitin-like modifier (SUMO) pathway in neurons. FMRP SUMOylation is induced by the activation of metabotropic glutamate receptors (mGlu5Rs). FMRP SUMOylation is required for dissociating FMRP from dendritic RNA granules and controlling spine density and proper maturation. Mechanically, the SUMOylation process is triggered by the activation of mGlu5Rs, thereby contributing to maintaining FMRP-mediated neuronal function. In fact, some proteins that mediate synaptic plasticity, neurotransmitter release, and neuronal network formation [2, 3, 4], are mostly regulated by SUMOylation. Therefore, SUMOylation has emerged as an essential posttranslational modification in the nervous system. This novel discovery first provides evidence to support the idea that FMRP is a novel substrate of SUMOylation and acts as an essential regulator in the developing brain. Clearly, it...
This highlight was supported by the National Natural Science Foundation of China (81503074).
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The authors declare that they have no conflict of interest.
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