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Neuroscience Bulletin

, Volume 35, Issue 1, pp 167–170 | Cite as

Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells

  • Xi-Yu Wang
  • Meihua Qu
  • Rui Duan
  • Dengping Shi
  • Ling Jin
  • Jinping Gao
  • Jackie D. Wood
  • Junhua LiEmail author
  • Guo-Du WangEmail author
Letter to the Editor
  • 42 Downloads

Dear Editor,

Body protection compound (BPC) 157 is a stable gastric pentadecapeptide. Predrag Sikiric’s team has carried out many investigations of its cytoprotective effects in different organs and tissues [1, 2]. Their evidence indicates that BPC157 has potent cytoprotection in neural injury and gastrointestinal (GI) ulcers. Nevertheless, the effects of BPC157 in the GI remain unclear. It is well known that the gut produces 95% of the 5-hydroxytryptamine (5-HT) in the human body. The 5-HT in the intestinal mucosa stimulates the production of pro-inflammatory mediators by immune cells. Enteric 5-HT may be a key player in physiological actions and the pathogenesis of intestinal inflammation [3, 4, 5]. Previous evidence has shown that enteric 5-HT plays a prominent role in inflammatory bowel disease [6, 7]. The reports imply that BPC157 significantly modulates the regional synthesis of 5-HT in different areas of the rat brain [8, 9]. So far, the detailed mechanism of action of BPC157...

Notes

Acknowledgments

We appreciate very much the gift of BPC157 from Dr. Predrag Sikiric in Zagreb, Croatia. This work was supported by a JMEY International collaboration Grant (020002015).

Supplementary material

12264_2018_269_MOESM1_ESM.pdf (233 kb)
Supplementary material 1 (PDF 234 kb)

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Xi-Yu Wang
    • 1
    • 3
    • 5
  • Meihua Qu
    • 4
  • Rui Duan
    • 1
  • Dengping Shi
    • 2
  • Ling Jin
    • 2
  • Jinping Gao
    • 2
  • Jackie D. Wood
    • 5
  • Junhua Li
    • 1
    Email author
  • Guo-Du Wang
    • 1
    • 3
    • 5
    Email author
  1. 1.Basic and Clinical Medical Research CenterJingmen First HospitalJingmenChina
  2. 2.Department of Gastroenterology and SurgeryJingmen Second HospitalJingmenChina
  3. 3.Department of Medicine, School of MedicineTulane UniversityNew OrleansUSA
  4. 4.School of PharmacyWeifang Medical UniversityWeifangChina
  5. 5.Department of Physiology, School of MedicineOhio State UniversityColumbusUSA

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