Effect of Gastrodin on Early Brain Injury and Neurological Outcome After Subarachnoid Hemorrhage in Rats

  • Xinzhi Wang
  • Shuyue Li
  • Jinbang Ma
  • Chuangang Wang
  • Anzhong Chen
  • Zhenxue XinEmail author
  • Jianjun ZhangEmail author
Original Article


Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease, but its effect in subarachnoid hemorrhage (SAH) remains unclear. In this study, we showed that intraperitoneal administration of gastrodin (100 mg/kg per day) significantly attenuated the SAH-induced neurological deficit, brain edema, and increased blood-brain barrier permeability in rats. Meanwhile, gastrodin treatment significantly reduced the SAH-induced elevation of glutamate concentration in the cerebrospinal fluid and the intracellular Ca2+ overload. Moreover, gastrodin suppressed the SAH-induced microglial activation, astrocyte activation, and neuronal apoptosis. Mechanistically, gastrodin significantly reduced the oxidative stress and inflammatory response, up-regulated the expression of nuclear factor erythroid 2–related factor 2, heme oxygenase-1, phospho-Akt and B-cell lymphoma 2, and down-regulated the expression of BCL2-associated X protein and cleaved caspase-3. Our results suggested that the administration of gastrodin provides neuroprotection against early brain injury after experimental SAH.


Subarachnoid hemorrhage Gastrodin Early brain injury Neuroprotection Neuronal apoptosis 



This work was supported by funds from the Project of Medical and Health Technology Development Program in Shandong Province, China (2016WS0196).

Conflict of interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Department of NeurosurgeryThe Second People’s Hospital of LiaochengLinqingChina
  2. 2.Department of Internal MedicineThe Second People’s Hospital of LiaochengLinqingChina
  3. 3.Department of Rehabilitation MedicineThe Second People’s Hospital of LiaochengLinqingChina

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