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Cutaneous Myeloid Sarcoma Mimicking Skin Cancer in Aleukemic Patients: a Diagnostic Challenge in Surgery

  • Karin Milleni Araujo
  • Barbara Rossi Galardino
  • Tatyane Freitas Carvalho
  • Viviane Alessandra Capelluppi-Tófano
  • Rafael DenadaiEmail author
Case Report
  • 4 Downloads

Abstract

Aleukemic cutaneous myeloid sarcoma is an extremely rare extramedullary manifestation of leukemia. Surgeons should be aware of the possibility of cutaneous myeloid sarcoma mimicking common skin cancer and consider it in the differential diagnoses when evaluating any patient with skin cancer-like lesions to ensure the prompt treatment of this potentially deadly cutaneous disease. We report three patients with presumed diagnoses of actinic keratosis and skin cancer, which actually turned out to be aleukemic cutaneous myeloid sarcoma.

Keywords

Cutaneous myeloid sarcoma Diagnosis Squamous cell carcinoma Basal cell carcinoma Clinical presentation Keratinocyte carcinoma 

Notes

Compliance with Ethical Standards

Conflict of Interest

Th authors declare that they have no conflict of interest.

Supplementary material

12262_2019_1984_MOESM1_ESM.pdf (1.6 mb)
ESM 1 (PDF 1658 kb)
12262_2019_1984_MOESM2_ESM.pdf (77 kb)
ESM 2 (PDF 76 kb)

References

  1. 1.
    Silfen R, Amir A, Regev D, Hauben DJ (2002) Role of physicians and patients in the diagnostic delay of cutaneous malignant melanoma. Ann Plast Surg 49:439–442CrossRefGoogle Scholar
  2. 2.
    Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127:2391–2405CrossRefGoogle Scholar
  3. 3.
    Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C (1985) Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med 103:620–625CrossRefGoogle Scholar
  4. 4.
    Aboutalebi A, Korman JB, Sohani AR, Hasserjian RP, Louissaint A Jr, Le L, Kraft S, Duncan LM, Nazarian RM (2013) Aleukemic cutaneous myeloid sarcoma. J Cutan Pathol 40:996–1005CrossRefGoogle Scholar
  5. 5.
    Cho-Vega JH, Medeiros LJ, Prieto VG, Vega F (2008) Leukemia cutis. Am J Clin Pathol 129:130–142CrossRefGoogle Scholar
  6. 6.
    Iliadis A, Koletsa T, Georgiou E, Patsatsi A, Sotiriadis D, Kostopoulos I (2016) Bilateral aleukemic myeloid sarcoma of the eyelids with indolent course. Am J Dermatopathol 38:312–314CrossRefGoogle Scholar
  7. 7.
    Chang H, Shih LY, Kuo TT (2003) Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature. Ann Hematol 82:435–439CrossRefGoogle Scholar
  8. 8.
    Narváez-Moreno B, Pereyra-Rodríguez JJ, Pulpillo-Ruiz A, Cabrera-Pérez R, Espigado-Tocino I, Conejo-Mir J (2015) Acute myeloid leukemia 7 years after aleukemic leukemia cutis. Int J Dermatol 54:459–461CrossRefGoogle Scholar

Copyright information

© Association of Surgeons of India 2019

Authors and Affiliations

  1. 1.Department of Dermatology, Pedro Ernesto University HospitalRio de Janeiro State University (HUPE-UERJ)Rio de JaneiroBrazil
  2. 2.Institute of Plastic and Craniofacial SurgerySOBRAPAR HospitalCampinasBrazil
  3. 3.Discipline of Hematology, School of Medical SciencesMarilia University (UNIMAR)MariliaBrazil

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