Heterotopic Brain Tissue in the Spinal Canal: a Report of an Unusual Case with a Review of the Literature
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Heterotopia refers to cells displaced from normal sites, when they are in an aberrant location within their organ of origin. Heterotopic neuroglial tissues are usually located in the nasal region. We present acase of a 69-year-old man with a long history of lumbosacral pain with paresis of the inferior limb. MRI examination detected a cystic tumor located at the L1-L2 level. Histologic examination revealed presence of heterotopic neuroglial tissues, containing synaptophysin, glial cells, and meninges.
KeywordsHeterotopic brain tissue Cystic tumor Lumbar spine canal
Ectopia and heterotopia both refer to cells displaced from normal sites, but ectopic cells occur outside of their organ of origin while heterotopic cells are in an aberrant location within their organ of origin . Heterotopic brain tissue (HBT) is an accumulation of mature brain tissue outside the physiological localization. Pathological masses are usually made of neuronal and glial cells but sometimes they also contain choroid plexus elements . This phenomenon was first described by Reid in 1852 . Despite the long history of observing similar lesions, heterotopic brain tissue is not a frequent occurrence. Fewer than 200 cases have been reported to this day . These anomalies where found in various locations but most commonly they were located in the nasal region [5, 6, 7]. To the best of our knowledge, no incidence of heterotopic brain tissue adjacent to the spinal cord in the lumbar region has been reported. The following case is all the more noteworthy because the abnormal tissue led to paresis of the inferior limb.
History and Examination
The patient was a 69-year-old man who presented with a long history of pain in the lumbosacral region. For about a month and a half, the patient was experiencing increasing back pain radiating to his right leg. The patient had a congenital lumbosacral spinal deformity and skin defect located in the lumbosacral region of the spine. Neurological examination showed decreased mobility and strength in the right inferior limb, 4/5 grade Lovett scale, and with atrophy of all muscle groups within the limb. Additionally, the patient reported hypoesthesia of the buttock and the superior region of the thigh of the right leg, and bowel incontinence.
Operation and Postoperative Course
An L1 and L2 laminectomy was performed, and the ligamentum flavum was excised. The dura mater was tense over the bulge of the tumor. The dura was opened with a midline incision. The lesion within the capsule contained thick, whitish fluid of cream-like consistency. Fluid of cystic tumor was aspirated and the capsule was excised. Neither destruction of bone nor any abnormality in the conus medullaris and nerve roots of the cauda equina was observed. The patient awoke with the same overall and neurological status as that before the surgery. He was discharged in good condition after 5 days of postoperative hospitalization. On the month of postoperative follow-up, the patient reported reduction of back pain and hypoesthesia.
Tissue of the cystic lesion obtained at surgery was fixed in 10% buffered formalin (pH = 7.4) and processed routinely through dehydration with graded alcohol, acetone, and xylene and then embedded in paraffin blocks. Four-micron-thick sections were stained with hematoxylin and eosin (H&E), and then other histochemical procedures such as Van Gieson and PAS followed. Sections for immunohistochemistry were mounted on slides coated with organosilane (Dako silanized slides, code no. S3003) to prevent floating of specimen during the immunohistochemical procedure. These sections were stained immunohistochemically using the EnVision™ Detection System (Dako Real™ EnVision™ Detection System, peroxidase/DAB+, rabbit/mouse, code no. K5007) with the following Dako antibodies: S-100 (code no. Z0311; dilution 1:100), GFAP (M0761; 1:100), synaptophysin (M0776; 1:20), EMA (M0613; 1:50), MIB-1 (M7240; 1:150), and CD34 (M7165; 1:50).
The pathogenesis of this kind of tissue is unclear. There are many theories which try to explain the origin of heterotopic brain tissue. One of them suggests that HBT may be due to separation of extracranial embryonic neuronal tissue through changes during cranial closure. It has been reported that 25% of nasal HBT lesions have a fibrous extradural connection to the central nervous system, which seems to confirm this theory . Another hypothesis suggests that HBT was derived from extracranial separation of embryonic neuronal tissue, which was independent of cranial closure. An alternative theory assumes that heterotopic lesions may result from isolated pluripotent neuroectodermal cells which then gradually transform into mature tissue [2, 4]. There are also some studies which suggest that genetic factors may contribute to neuronal overmigration and neuronal ectopia . On the other hand, no familial tendency and gender preference connections were found in relation to the occurrence of HBT .
The case we present is unusual in many terms. In the observations carried out so far, the most common location of heterotopic brain tissue was the nasal region . In 60% of these cases, the lesions occurred extranasally, usually on the midline over the bridge of the nose. Thirty percent of them were located intranasally along the lateral wall of the nose. Location in 10% was combined . Non-nasal location was less frequent; however, ectopic brain tissue has been reported to occur in the pharynx, lung, orbits, palate, tongue, cheek, lips, and neck [5, 6]. As previously mentioned, according to our knowledge, this is the first case of heterotopic brain tissue adjacent to the spinal cord in the lumbar region that has been reported.
Majority of the times, heterotopic neuronal tissues were found in early infancy or childhood. However, there have been several cases of lesions in older age, as in our case [10, 11]. This situation may result from the fact that HBT lesions are usually asymptomatic and they are often discovered incidentally for unrelated reason by imaging examination . In symptomatic cases, the manifestations are mainly due to the mass effect. Lesions in the nasal area quite often cause respiratory difficulties due to compression of the airway . In our case, the presence of heterotopic brain tissue adjacent to the spinal cord led to compression of nerve fibers and paresis of the inferior limb. Destruction of surrounding tissues in the case of HBT is caused by the mass effect. There are no reports of malignant degeneration in heterotopic brain tissue .
Due to the asymptomatic nature of the changes, treatment is often unnecessary. Surgical procedures are indicated in symptomatic cases in which it may bring relief of symptoms . In the case of our patient, the treatment caused a reduction of back pain and hypoesthesia. The relapse rate after surgical treatment of the heterotopic brain tissue is low. It is claimed that it ranges from 4 to 10% .
In summary, heterotopic neuroglial tissue in the lumbar spinal canal is a very uncommon lesion, and preoperative diagnosis of this lesion is difficult. Imaging studies and histologic examination are the necessary investigations for diagnosis. Surgical treatment is the best choice for a symptomatic patient with pathological lesion in the spinal canal. The outcome is similar to other benign lesions in this location.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
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