Advertisement

Male Breast Cancer—an Indian Multicenter Series of 106 Cases

  • M. K. ChhabraEmail author
  • Chintamani
  • G. Kadyaprath
  • A. Srivastva
  • V. Selvakumar
  • P. Ranjan
  • C. K. Durga
  • S. Thomas
  • N. Kaur
  • M. Singh
  • M. Govil
  • A. Gupta
Original Article
  • 11 Downloads

Abstract

Male breast cancer (MBC) accounts for < 1% of all breast cancers. The available data on male breast cancer is mainly retrospective institution-based studies. Due to the scarcity of the disease, randomized controlled trials have not been feasible. Conducting a multicenter study is the next best option to assess the effectiveness of the treatment which is currently followed as per the guidelines on female breast cancer (FBC). Under the aegis of Delhi Breast Oncology Group (DBOG), data of 106 MBC patients was collected from 11 leading hospitals of Delhi and analyzed from January 2010 to April 2017. The age of the patients ranged from 35 to 82 years with a median of 59 years. The commonest presentation was a lump in the breast (98%). There was a delay in presentation of 1–6 months in the majority (86%) of cases. of the total number of patients, 51% had Stage II, 25% Stage III, 18% Stage I, 4% Stage 0, and 2% Stage IV breast cancer at the time of presentation. Infiltrating ductal carcinoma was the commonest histopathological finding. IHC receptor studies revealed ER positivity in 81% and PR positivity in 76%. HER2 neu positivity was seen in 25% of cases. Modified radical mastectomy was the commonest (92%) surgical procedure. Of the total number of cases, 18% received neoadjuvant chemotherapy, 35% received adjuvant chemotherapy, 32% underwent radiotherapy, and 74% received hormonal therapy. The 5-year cumulative disease-free survival was 60.7%. MBC is rare and unique. There are differences from FBC with respect to time of presentation, aggressiveness, histopathology, IHC markers, and response to treatment with a poorer outcome. Multicentric prospective studies are recommended for future research.

Keywords

Male breast cancer Female breast cancer Risk factors Prognosis Mastectomy Radiotherapy Chemotherapy Hormonal therapy 

Notes

References

  1. 1.
    Liu N, Johnson KJ, Ma CX (2018 Oct) Male breast cancer: an updated surveillance, epidemiology, and end results data analysis. Clin Breast Cancer 18(5):e997–e1002.  https://doi.org/10.1016/j.clbc.2018.06.013 CrossRefGoogle Scholar
  2. 2.
    Anderson WF, Jatoi I, Tse J, PSR (2010) Male breast cancer: a population-based comparison with female breast cancer. J Clin Oncol 28:232–239.  https://doi.org/10.1200/JCO.2009.23.8162 CrossRefGoogle Scholar
  3. 3.
    Miao H, Verkooijen HM, Chia KS, Bouchardy C, Pukkala E, Larønningen S, Mellemkjær L, Czene K, Hartman M (2011) Incidence and outcome of male breast cancer: an international population-based study. J Clin Oncol 29:4381–4386.  https://doi.org/10.1200/JCO.2011.36.8902 CrossRefGoogle Scholar
  4. 4.
    Sasco AJ (1993) Review article: epidemiology of male breast cancer. A meta-analysis of published case-control studies and discussion of selected aetiological factors. Int J Cancer 53:538–549 =4CrossRefGoogle Scholar
  5. 5.
    Shah P, Robbani I, Shah O (2009) Clinicopathological study of male breast carcinoma: 24 years of experience. Ann Saudi Med 29(4):288–293.  https://doi.org/10.4103/0256-4947.55314 CrossRefGoogle Scholar
  6. 6.
    Shukla NK, Seenu V, Goel AK, Raina V, Rath GK, Singh R (1996) Male breast cancer: a retrospective study from a regional cancer center in northern India. J Surg Oncol 61:143–148.  https://doi.org/10.1002/(SICI)1096-9098(199602)61:2<143::AID-JSO10>3.0.CO;2-A CrossRefGoogle Scholar
  7. 7.
    Ghoshal S, Rai B, Sharma SC (2005) Breast cancer in males: a PGIMER experience. J Cancer Res Ther 1:31–33.  https://doi.org/10.4103/0973-1482.16087 CrossRefGoogle Scholar
  8. 8.
    Gogia A, Raina V, Deo S et al (2015) Male breast cancer: a single institute experience. Indian J Cancer 52:526.  https://doi.org/10.4103/0019-509X.178399 CrossRefGoogle Scholar
  9. 9.
    Chikaraddi S, Krishnappa R, Deshmane V (2012) Male breast cancer in Indian patients: is it the same? Indian J Cancer 49:272.  https://doi.org/10.4103/0019-509X.104484 CrossRefGoogle Scholar
  10. 10.
    Mukherjee A, Saha A, Chattopadhyay S, Sur PK (2014) Clinical trends and outcomes of male breast cancer: experience of a tertiary oncology centre in India Original Article Abstract. Int J Cancer Ther Oncol 2:1–8.  https://doi.org/10.14319/ijcto.0203.5 CrossRefGoogle Scholar
  11. 11.
    Sundriyal D, Kotwal S, Dawar R, Parthasarathy KM (2015) Male breast cancer in India: series from a cancer research centre. Indian J Surg Oncol 6:384–386.  https://doi.org/10.1007/s13193-015-0473-1 CrossRefGoogle Scholar
  12. 12.
    Patel R, Kumar R, Pandya SJ, Mendiratta P (2016) Male breast cancer: single institutional experience at Gujarat Cancer & Research institute. Int J Curr Adv Res 5:1203–1204Google Scholar
  13. 13.
    Ram D, Rajappa SK, Selvakumar VP, Shukla H, Goel A, Kumar R, Kumar K (2017) Male breast cancer: a retrospective review of clinical profile from a tertiary care center of India. South Asian I Cancer 6(4):141–143.  https://doi.org/10.4103/sajc.sajc_2_17 CrossRefGoogle Scholar
  14. 14.
    Cutuli B, Le-Nir CCS, Serin D et al (2010) Male breast cancer. Evolution of treatment and prognostic factors. Analysis of 489 cases. Crit Rev Oncol Hematol 73:246–254.  https://doi.org/10.1016/j.critrevonc.2009.04.002 CrossRefGoogle Scholar
  15. 15.
    Fentiman IS, Fourquet A, Hortobagyi GN (2006) Male breast cancer. Lancet 367:595–604CrossRefGoogle Scholar
  16. 16.
    Samuelson MH (2006) Breast cancer: not for women only. Lancet 367:605.  https://doi.org/10.1016/S0140-6736(06)68227-5 CrossRefGoogle Scholar
  17. 17.
    Rudlowski C (2008) Male breast cancer. Breast Care (Basel) 3:183–189.  https://doi.org/10.1159/000136825 CrossRefGoogle Scholar
  18. 18.
    Erren TC (2001) A meta-analysis of epidemiologic studies of electric and magnetic fields and breast cancer in women and men. Bioelectromagnetics Suppl 5:S105–S119CrossRefGoogle Scholar
  19. 19.
    Brinton LA, Carreon JD, Gierach GL, McGlynn KA, Gridley G (2010) Etiologic factors for male breast cancer in the U.S. veteran affairs medical care system database. Breast Cancer Res Treat 119(1):185–192.  https://doi.org/10.1007/s10549-009-0379-0 Epub 2009 Mar 29CrossRefGoogle Scholar
  20. 20.
    McLachlan SA, Erlichman C, Liu FF et al (1996) Male breast cancer: an 11 year review of 66 patients. Breast Cancer Res Treat 40:225–230.  https://doi.org/10.1007/BF01806810 CrossRefGoogle Scholar
  21. 21.
    Onami S, Ozaki M, Mortimer JE, Kumar S (2010) Male breast cancer: an update in diagnosis, treatment and molecular profiling. Maturitas 65:308–314.  https://doi.org/10.1016/j.maturitas.2010.01.012 CrossRefGoogle Scholar
  22. 22.
    Gómez-Raposo C, ZambranaTévar F, Moyano MS, Miriam López Gómez EC (2010) Male breast cancer. Cancer Treat Rev 36:451–457CrossRefGoogle Scholar
  23. 23.
    Fentiman IS (2018) The endocrinology of male breast cancer. Endocr Relat Cancer 25(6):R365–R373.  https://doi.org/10.1530/ERC-18-0117 CrossRefGoogle Scholar
  24. 24.
    Weir J, Zhao YD, Herman T, Algan Ö (2018) Clinicopathologic features and radiation therapy utilization in patients with male breast cancer: a national cancer database study. Breast Cancer Basic Clin Res 12:117822341877068.  https://doi.org/10.1177/1178223418770687 CrossRefGoogle Scholar
  25. 25.
    Cloyd JM, Hernandez-Boussard T, Wapnir IL (2013 May) Poor compliance with breast cancer treatment guidelines in men undergoing breast-conserving surgery. Breast Cancer Res Treat 139(1):177–182.  https://doi.org/10.1007/s10549-013-2517-y CrossRefGoogle Scholar
  26. 26.
    Golshan M, Rusby J, Dominguez F, Smith BL (2007) Breast conservation for male breast carcinoma. Breast 16(6):653–656 Epub 2007 Jul 2 CrossRefGoogle Scholar
  27. 27.
    Goyal A, Horgan K, Kissin M, Yiangou C, Sibber-ing M, Lansdown M, Newcombe RG, Mansel RE, Chetty U, Ell P, Fallowfield L, Kissin M (2004) Sentinel lymph node biopsy in male breast cancer patients. Eur J Surg Oncol 30:480–483CrossRefGoogle Scholar
  28. 28.
    Giordano SH, Perkins GH, Broglio K, Garcia SG, Middleton LP, Buzdar AU, Hortobagyi GN (2005) Adjuvant systemic therapy for male breast carcinoma. Cancer 104:2359–2364.  https://doi.org/10.1002/cncr.21526 CrossRefGoogle Scholar
  29. 29.
    Ottini L, Palli D, Rizzo S, Federico M, Bazan V, Russo A (2010) Male breast cancer. Crit Rev Oncol Hematol 73:141–155CrossRefGoogle Scholar
  30. 30.
    Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, Bartlett JMS, Gelmon K, Nahleh Z, Bergh J, Cutuli B, Pruneri G, McCaskill-Stevens W, Gralow J, Hortobagyi G, Cardoso F (2010) Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol 28:2114–2122.  https://doi.org/10.1200/JCO.2009.25.5729 CrossRefGoogle Scholar

Copyright information

© Association of Surgeons of India 2019

Authors and Affiliations

  • M. K. Chhabra
    • 1
    Email author
  • Chintamani
    • 2
  • G. Kadyaprath
    • 3
  • A. Srivastva
    • 4
  • V. Selvakumar
    • 5
  • P. Ranjan
    • 4
  • C. K. Durga
    • 6
  • S. Thomas
    • 7
  • N. Kaur
    • 8
  • M. Singh
    • 9
  • M. Govil
    • 10
  • A. Gupta
    • 11
  1. 1.Deen Dayal Upadhyay HospitalNew DelhiIndia
  2. 2.Vardhman Mahavir Medical CollegeSafdarjang HospitalNew DelhiIndia
  3. 3.Breast Surgical Oncology, Max Institute of Cancer CareMax Hospital, Patparganj and VaishaliDelhi-NCRIndia
  4. 4.Department of Surgical DisciplinesAIIMSNew DelhiIndia
  5. 5.Breast Oncology, Max institute of cancer care Shalimar BaghNew DelhiIndia
  6. 6.Department of SurgeryPGIMER RML HospitalNew DelhiIndia
  7. 7.Department of SurgeryLady Hardinge Medical CollegeNew DelhiIndia
  8. 8.Department of SurgeryUCMS & GTB HospitalNew DelhiIndia
  9. 9.Department of Head, Neck and Breast OncoplastyFortis Hospital Vasant KunjNew DelhiIndia
  10. 10.Department of SurgeryIGESI Hospital, JhilmilNew DelhiIndia
  11. 11.Acharya Shree Bhikshu Hospital, Moti NagarNew DelhiIndia

Personalised recommendations