Bladder Sparing Approach in Carcinosarcoma of Urinary Bladder
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Carcinosarcoma of the bladder is a very rare tumor. This tumor contains both the sarcoma element from mesenchymal lineage and the carcinoma element from epithelial cells. Some investigators feel that these tumors develop as a result of the capability of the undifferentiated, totipotent neoplastic cell to undergo multiple pathways of terminal differentiation into histologically recognizable mesenchymal and epithelial elements. The mesenchymal component may be expressed as a variety of histologic types, including chondrosarcoma, leiomyosarcoma, osteogenic sarcoma, and rhabdomyosarcoma. The epithelial component may be most frequently found in the form of transitional cell carcinoma, adenocarcinoma, or in an admixture of these. Urinary bladder tumor showing cartilaginous and osseous differentiation is very rare. They usually present in advanced stage. Radical cystectomy with chemoradiotherapy is the treatment of choice for urinary bladder carcinosarcoma. We present such a unique case where TURBT combined with radio chemotherapy helped in preserving the bladder with no recurrence until 2 years.
KeywordsCarcinosarcoma TURBT Urinary bladder Mesenchymal tumor Chemotherapy Radiotherapy