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Indian Journal of Surgery

, Volume 81, Issue 5, pp 462–467 | Cite as

Primary Diffuse Large B Cell Lymphoma of Thyroid Gland; Germinal Center and Non-germinal Center B Types: Experience of a Single Center

  • Hale DemirEmail author
  • Hilal Aki
  • Ayse Salihoglu
  • Nil Comunoglu
  • Haydar Durak
Original Article
  • 21 Downloads

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype accounting for approximately 70% of primary thyroid lymphoma (PTL) cases. Its prognosis depends on the histology, spread, and the stage of the disease. DLBCL usually displays a better prognosis, but it shows heterogeneity according to the histological subtype. Germinal center B cell (GCB) subtype has a more favorable prognosis than the non-germinal center (non-GCB) subtype. Most of these patients required combined modality management. This study included eight patients with stage I/IIE thyroid DLBCL. Analysis of clinicopathologic features of all PTL patients diagnosed at Cerrahpasa Faculty of Medicine. Pathology reports and slides of patients diagnosed between years of 2000 and 2013 were evaluated. Four of them were GCB and the other four cases were non-GCB type. All patients underwent thyroidectomy. Three of them were treated with chemotherapy and the three patients were treated with chemotherapy followed by radiotherapy. Five patients are presently alive. Due to the fact that PTLs are rare types of tumors, only small case series were published in that field. Increasing the number of cases in the literature for thyroid DLBCL, its histopathologic features will provide a better understanding.

Keywords

Thyroid Primary diffuse large B cell lymphoma Germinal center B type Non-germinal center B type Immunophenotype 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that there is no conflict of interest.

References

  1. 1.
    Sakorafas GH, Kokkoris P, Farley DR (2010) Primary thyroid lymphoma (correction of lymphoma): diagnostic and therapeutic dilemmas. Surg Oncol 19:124–129CrossRefGoogle Scholar
  2. 2.
    Sarinah B, Hisham AN (2010) Primary lymphoma of the thyroid: diagnostic and therapeutic considerations. Asian J Surg 33:20–24CrossRefGoogle Scholar
  3. 3.
    Thieblemont C, Mayer A, Dumontet C, Barbier Y, Callet-Bauchu E, Felman P, Berger F, Ducottet X, Martin C, Salles G, Orgiazzi J, Coiffier B (2002) Primary thyroid lymphoma is a heterogeneous disease. J Clin Endocrinol Metab 87:105–111CrossRefGoogle Scholar
  4. 4.
    Derringer GA, Thompson LD, Frommelt RA et al (2000) Malignant lymphoma of the thyroid gland: a clinicopathologic study of 108 cases. Am J Surg Pathol 24:623–639CrossRefGoogle Scholar
  5. 5.
    Matsuzuka F, Miyauchi A, Katayama S et al (1993) Clinical aspects of primary thyroid lymphoma: diagnosis and treatment based on our experience of 119 cases. Thyroid 3:93–99CrossRefGoogle Scholar
  6. 6.
    Stein SA, Wartofsky L (2013) Primary thyroid lymphoma: a clinical review. J Clin Endocrinol Metab 98:3131–3138CrossRefGoogle Scholar
  7. 7.
    Niitsu N, Okamoto M, Nakamura N, Nakamine H, Aoki S, Hirano M, Miura I (2007) Prognostic impact of chromosomal alteration of 3q27 on nodal B-cell lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 329 consecutive patients. Leuk Res 31:1191–1197CrossRefGoogle Scholar
  8. 8.
    Watanabe N, Noh JY, Narimatsu H, Takeuchi K, Yamaguchi T, Kameyama K, Kobayashi K, Kami M, Kubo A, Kunii Y, Shimizu T, Mukasa K, Otsuka F, Miyara A, Minagawa A, Ito K, Ito K (2011) Clinicopathological features of 171 cases of primary thyroid lymphoma: a long-term study involving 24553 patients with Hashimoto’s disease. Br J Haematol 153:236–243CrossRefGoogle Scholar
  9. 9.
    Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J (2000) Lymphoma classification--from controversy to consensus: the R.E.A.L. and WHO classification of lymphoid neoplasms. Ann Oncol 11:3–10CrossRefGoogle Scholar
  10. 10.
    Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Müller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, Falini B, Banham AH, Rosenwald A, Staudt LM, Connors JM, Armitage JO, Chan WC (2004) Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103:275–282CrossRefGoogle Scholar
  11. 11.
    Graff-Baker A, Roman SA, Thomas DC, Udelsman R, Sosa JA (2009) Prognosis of primary thyroid lymphoma: demographic, clinical, and pathologic predictors of survival in 1,408 cases. Surgery 146:1105–1115CrossRefGoogle Scholar
  12. 12.
    Belal AA, Allam A, Kandil A, Husseiny GE, Khafaga Y, Rajhi NA, Ahmed G, Gray A, Ajarim D, Schultz H, Ezzat A (2001) Primary thyroid lymphoma: a retrospective analysis of prognostic factors and treatment outcome for localized intermediate and high grade lymphoma. Am J Clin Oncol 24:299–305CrossRefGoogle Scholar
  13. 13.
    Sun TQ, Zhu XL, Wang ZY, Wang CF, Zhou XY, Ji QH, Wu Y (2010) Characteristics and prognosis of primary thyroid non-Hodgkin’s lymphoma in Chinese patients. J Surg Oncol 101:545–550CrossRefGoogle Scholar

Copyright information

© Association of Surgeons of India 2018

Authors and Affiliations

  • Hale Demir
    • 1
    Email author
  • Hilal Aki
    • 1
  • Ayse Salihoglu
    • 2
  • Nil Comunoglu
    • 1
  • Haydar Durak
    • 1
  1. 1.Cerrahpasa School of Medicine, Department of PathologyIstanbul UniversityIstanbulTurkey
  2. 2.Cerrahpasa School of Medicine, Department of Internal MedicineIstanbul UniversityIstanbulTurkey

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