Characteristics and Mechanism of Microwave-assisted Drying of Amorphous Paclitaxel for Removal of Residual Solvent
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We investigated the characteristics and mechanism of microwave-assisted drying of amorphous paclitaxel for the removal of residual solvent, acetonitrile. The removal efficiency of residual acetonitrile increased with increasing drying temperature from 35 to 55°C. When the experimental data were applied to typical kinetic models, the Page model was determined to be the most suitable. Thermodynamic parameters revealed the spontaneous and endothermic nature of microwave-assisted drying. The effective diffusion coefficient of acetonitrile (0.865 × 10−8∼ 1.553 × 10−8 m2/s) and the convective mass transfer coefficient (2.138 × 10−7∼7.656 × 10−7 m/s) increased with increasing drying temperature. The small Biot number (0.001975∼ 0.003939) indicated that the process of mass transfer was externally controlled.
Keywordsamorphous paclitaxel microwave-assisted drying characteristics effective diffusivity mass transfer coefficient
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This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Korean Ministry of Education, Science and Technology (Grant Number: 2018R1D1A3A03000683).
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