Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

  • Mi Na Rhie
  • Hee Taek Kim
  • Seo Young Jo
  • Luan Luong Chu
  • Kei-Anne Baritugo
  • Mary Grace Baylon
  • Jinwon Lee
  • Jeong-Geol Na
  • Lyul Ho Kim
  • Tae Wan Kim
  • Chulhwan Park
  • Soon Ho Hong
  • Jeong Chan JooEmail author
  • Si Jae ParkEmail author
Review Paper


The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of biobased chemicals.


Klebsiella pneumoniae biorefinery metabolic engineering microbial cell factory carbon utilization biomass 


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Copyright information

© The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Mi Na Rhie
    • 1
  • Hee Taek Kim
    • 2
  • Seo Young Jo
    • 1
  • Luan Luong Chu
    • 1
  • Kei-Anne Baritugo
    • 1
  • Mary Grace Baylon
    • 1
  • Jinwon Lee
    • 3
  • Jeong-Geol Na
    • 3
  • Lyul Ho Kim
    • 3
  • Tae Wan Kim
    • 4
  • Chulhwan Park
    • 5
  • Soon Ho Hong
    • 6
  • Jeong Chan Joo
    • 2
    Email author
  • Si Jae Park
    • 1
    Email author
  1. 1.Division of Chemical Engineering and Materials ScienceEwha Womans UniversitySeoulKorea
  2. 2.Bio-based Chemistry Research Center, Advanced Convergent Chemistry DivisionKorea Research Institute of Chemical TechnologyDaejeonKorea
  3. 3.Department of Chemical and Biomolecular EngineeringSogang UniversitySeoulKorea
  4. 4.Department of Biotechnology and BioengineeringChonnam National UniversityGwangjuKorea
  5. 5.Department of Chemical EngineeringKwangwoon UniversitySeoulKorea
  6. 6.Department of Chemical EngineeringUniversity of UlsanUlsanKorea

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