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Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis

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Abstract

Batch experimental studies were carried out for the ultrasound-assisted extraction of paclitaxel from Taxus chinensis while varying parameters such as ultrasound power, extraction temperature and contact time. The extraction of the majority of the paclitaxel (~99%) was achieved from the biomass by a single extraction at 380W of ultrasound power for a period of 10 min. The kinetics data obtained for the paclitaxel extractions, and the dominant role played by intraparticle diffusion, were found to be in concordance with the pseudo-second-order model, and the intraparticle diffusion model respectively. The effective diffusion coefficient of paclitaxel (4.1882 × 10-13 ~ 5.7093 × 10-13 m2/s) and the mass transfer coefficient (4.705 × 10-8 ~ 14.1160 × 10-8 m/s) increased when the extraction temperature and ultrasound power were raised.

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Authors and Affiliations

  1. Department of Chemical Engineering, Kongju National University, Cheonan, 330-717, Korea

    Kyung-Wan Yoo & Jin-Hyun Kim

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  1. Kyung-Wan Yoo
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Yoo, KW., Kim, JH. Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis. Biotechnol Bioproc E 23, 532–540 (2018). https://doi.org/10.1007/s12257-018-0190-z

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  • DOI: https://doi.org/10.1007/s12257-018-0190-z

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